Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …

We are still very limited in management strategies for dementia, and establishing effective
disease modifying therapies based on amyloid or tau remains elusive. Neuroinflammation …

Peripheral-type benzodiazepine receptors (PBRs) are abundant in the cardiovascular
system. In the cardiovascular lumen, PBRs are present in platelets, erythrocytes …

Epilepsy is a chronic disease of the central nervous system characterized by recurrent
epileptic seizures. As a result of epileptic seizure or status epilepticus oxidants are …

Once considered simply as the main source of ATP, mitochondria are now implicated in the
control of many additional aspects of cell physiology, such as calcium signaling, and …

The high incidence of age-related diseases in the increasing population of elderly people
has stimulated interest in the search for protective agents that have the capability of …

[11C] PK11195 is used in positron emission tomography (PET) studies for imaging brain
inflammation in vivo as it binds to the peripheral-type benzodiazepine receptor (PBR) …

Translocator protein 18 kDa (TSPO) is a mitochondrial outer membrane protein. Although
TSPO expression is up-regulated during neuroinflammation, the role of TSPO and its …

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disease
characterized by progressive motor, psychiatric, and cognitive abnormalities. The …