This article reviews the metabolic pharmacokinetic drug-drug interactions with the systemic
antifungal agents: the azoles ketoconazole, miconazole, itraconazole and fluconazole, the …

Carbamazepine is one of the most commonly prescribed antiepileptic drugs and is also
used in the treatment of trigeminal neuralgia and psychiatric disorders, particularly bipolar …

Itraconazole (ITZ) is a potent inhibitor of CYP3A in vivo. However, unbound plasma
concentrations of ITZ are much lower than its reported in vitro K i, and no clinically significant …

There are 3 main classes of systemic antifungals: the polyene macrolides (eg amphotericin
B), the azoles (eg the imidazoles ketoconazole and miconazole and the triazoles …

Synopsis Itraconazole is an orally administered triazole antifungal agent Its spectrum of
activity includes dermatophyte, dimorphic and dematiaceous fungi, yeasts, and some …

Itraconazole is a new triazole compound with a broad spectrum of activity against a number
of fungal pathogens, including Aspergillus species. The drug is being used increasingly as …

Drug-drug interactions are a recurring problem in immunocompromised patients treated with
triazole antifungals. While the introduction of new antifungals has expanded opportunities …

Pharmacokinetic interactions involving anti-infective drugs may be important in the intensive
care unit (ICU). Although some interactions involve absorption or distribution, the most …

Onychomycosis is caused by infection by fungi, mainly dermatophytes and
nondermatophyte yeasts or moulds; it affects the fingernails and, more frequently, the …

A drug interaction develops when the effect of a drug is increased or decreased or when a
new effect is produced by the prior, concurrent, or subsequent administration of the other …