Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Metabolic programming and mitochondrial dynamics along with T cell differentiation affect T
cell fate and memory development; however, how to control metabolic reprogramming and …

Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …

The health benefits of regular exercise are well established. Nonetheless, the molecular
mechanism (s) responsible for exercise-induced health benefits remain a topic of debate …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

The metabolic program is altered during macrophage activation and influences macrophage
polarization. Glutaminolysis promotes accumulation of α-ketoglutarate (αKG), leading to …

The low-density lipoprotein (LDL) is a major cholesterol carrier in circulation and is
internalized into cells through LDL receptor (LDLR)-mediated endocytosis. The LDLR …

Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in
regulating diverse cellular processes including gene expression, cell cycle progression …