The last decades have seen a tremendous expanse in the application of C H activation of
many different substrate classes, including the invaluable indole scaffold. Following the …

The nitrile or cyano (–CN) group is one of the most appreciated and effective functional
groups in organic synthesis, having a polar unsaturated C–N triple bond. Despite sufficient …

Over the last two decades, transition-metal catalyzed C–H functionalization of indoles has
emerged as an area of extensive research and tremendous progress has been made in this …

Esters are valuable electrophiles for cross-coupling due to their ubiquity and ease of
synthesis. However, harsh conditions are traditionally required for the effective cross …

Chemo-enzymatic reactions have received great attention for asymmetric synthesis, but
most reported systems use only one-or two-step enzymatic reactions for relatively simple …

A new class of bidentate ligands was prepared by a modular approach involving Rh-
catalyzed C–H annulation reactions. The resulting conformationally constrained ligands …

Excessive exposure of UV radiation from the sunlight to human skin is dangerous and
causes various skin disorders including skin cancer. Dermatologists worldwide recommend …

We have demonstrated the first ever example of nickel complexes as effective catalysts to
promote the C–C, N–C cascade coupling of ketonitriles with arylboronic acids, affording …

Blocking the de novo biosynthesis of pyrimidine by inhibiting human dihydroorotate
dehydrogenase (hDHODH) is an effective way to suppress the proliferation of cancer cells …

A novel and efficient protocol for the synthesis of various 2, 4-disubstituted, 1, 2, 4-
trisubstituted and 1, 2, 4, 5-tetra-substituted imidazoles via cascade palladium catalyzed C …