The tumour microenvironment is the primary location in which tumour cells and the host
immune system interact. Different immune cell subsets are recruited into the tumour …

The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …

Neutrophils act as the first line of defense against invading pathogens. Although traditionally
considered in context of their antimicrobial effector functions, the importance of tumor …

After a century of controversy, the notion that the immune system regulates cancer
development is experiencing a new resurgence. An overwhelming amount of data from …

Mesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional
differentiation potential and strong immunomodulatory capacity. MSCs have been widely …

We previously identified the angiogenesis inhibitor angiostatin. Using a similar strategy, we
have identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma …

The success of antitumor immune responses depends on the infiltration of solid tumors by
effector T cells, a process guided by chemokines. Here we show that in vivo post …

To identify the molecular basis underlying the functions of tumor-associated macrophages
(TAMs), we characterized the gene expression profile of TAMs isolated from a murine …

Although several CXC chemokines have been shown to induce angiogenesis and play roles
in tumor growth, to date, no member of the CC chemokine family has been reported to play a …

To evaluate the hypothesis that the proinflammatory cytokines IL-1, IL-6, and tumor necrosis
factor-α might be the link between prenatal intrauterine infection (IUI) and neonatal brain …