Despite the wealth of information on cannabinoid-induced peripheral antihyperalgesic and
antinociceptive effects in many pain models, the molecular mechanism (s) for these actions …

Cancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent
diseases, and current treatments rely primarily on opioids, which have significant side …

Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine involved in the development
and maintenance of inflammatory and neuropathic pain conditions. The mechanisms by …

Considerable attention has been given to the use of chitosan (CS)‐based materials
reinforced with inorganic bioactive signals such as hydroxyapatite (HA) to treat bone defects …

Objectives: To perform a topical review of the published literature on painful neuromas.
Methods: A MEDLINE search was performed using the MESH terms “neuroma”,“pain”,“ …

Neuropathic pain (NP) is a significant and disabling clinical problem with very few
therapeutic treatment options available. A major priority is to identify the molecular …

Humans have used Cannabis sativa (marijuana) for at least 12,000 years, but researchers
have only recently described an endogenous cannabinoid system. The endocannabinoid …

Background Traumatic neuromas are rare benign tumors, which are common in trauma or
post-operation and accompanied with obvious symptoms of pain. This study will show the …

Flavonoids are increasingly ingested by the population as chemotherapeutic and anti-
inflammatory agents. Myricetin is a naturally occurring flavonoid known for its anti-neoplastic …

It is known that application of tumor-necrosis-factor-α (TNF-α) sensitizes neuronal calcium
channels for heat stimuli in rat models of neuropathic pain. This study examines whether …