The role and mechanisms of action of microRNAs in cancer drug resistance
W Si, J Shen, H Zheng, W Fan - Clinical epigenetics, 2019 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …
can regulate various target genes and are thus involved in the regulation of a variety of …
MicroRNAs, regulatory messengers inside and outside cancer cells
MicroRNAs (miRNAs) are a class of short non-coding RNAs (ncRNAs) with typical sequence
lengths of 19–25 nucleotides and extraordinary abilities to regulate gene expression …
lengths of 19–25 nucleotides and extraordinary abilities to regulate gene expression …
The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma
Somatic copy number variations (CNV) may drive cancer progression through both coding
and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely …
and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely …
[HTML][HTML] RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
J George, Y Li, IP Kadamberi, D Parashar, SW Tsaih… - Cell reports, 2021 - cell.com
Summary Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian
cancer, and this amplification is associated with increased expression of both FXR1 mRNA …
cancer, and this amplification is associated with increased expression of both FXR1 mRNA …
miRNA551b-3p activates an oncostatin signaling module for the progression of triple-negative breast cancer
Summary Genomic amplification of 3q26. 2 locus leads to the increased expression of
microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results …
microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results …
Peritoneal spread of ovarian cancer harbors therapeutic vulnerabilities regulated by FOXM1 and EGFR/ERBB2 signaling
Peritoneal spread is the primary mechanism of metastasis of ovarian cancer, and survival of
ovarian cancer cells in the peritoneal cavity as nonadherent spheroids and their adherence …
ovarian cancer cells in the peritoneal cavity as nonadherent spheroids and their adherence …
Direct upregulation of STAT3 by MicroRNA-551b-3p deregulates growth and metastasis of ovarian cancer
Summary 3q26. 2 amplification in high-grade serous ovarian cancer leads to increased
expression of mature microRNA miR551b-3p, which is associated with poor clinical …
expression of mature microRNA miR551b-3p, which is associated with poor clinical …
Patient-derived ovarian cancer spheroids rely on PI3K-AKT signaling addiction for cancer stemness and chemoresistance
D Parashar, A Geethadevi, S Mittal, LA McAlarnen… - Cancers, 2022 - mdpi.com
Simple Summary Epithelial ovarian cancer (EOC) is the most fatal gynecological cancer with
poor survival rates and high mortality. EOC patients respond to standard platinum-based …
poor survival rates and high mortality. EOC patients respond to standard platinum-based …
Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells
KA Dorsett, RB Jones, KE Ankenbauer… - Journal of ovarian …, 2019 - Springer
Abstract Background The ST6Gal-I glycosyltransferase, which adds α2–6-linked sialic acids
to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian …
to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian …
Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms
A Emadali, N Hoghoughi, S Duley… - Blood, The Journal …, 2016 - ashpublications.org
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive
leukemia for which knowledge on disease mechanisms and effective therapies are currently …
leukemia for which knowledge on disease mechanisms and effective therapies are currently …