Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous
vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially …

Fruit and vegetables are essential components of a healthy diet. The World Health
Organization (WHO) recommends an intake of five to eight portions (400–600 g) daily of …

Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-
regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). AMP-activated protein kinase …

Chlorogenic acid (CGA) is a natural polyphenol compound abundant in green plants with
antioxidant and anti-inflammatory activities. Here, we explore its protective effects and …

Joint conditions pose an important public health problem as they are a leading cause of
pain, functional limitation and physical disability. Oxidative stress is related to the …

An accumulation of misfolded proteins can trigger a cellular survival response in the
endoplasmic reticulum (ER). In this study, we found that ER stress–associated gene …

Rheumatoid arthritis is one of the most prevalent, chronic, inflammatory disorders involving
multiple articular and extra-articular complications. Immune deregulation owing to a …

The activity and function of T-cells are influenced by the intra-and extracellular redox milieu.
Oxidative stress induces hypo responsiveness of untransformed T-cells. Vice versa …

Defective apoptotic death of activated macrophages has been implicated in the
pathogenesis of rheumatoid arthritis (RA). However, the molecular signatures defining …

Abstract Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular
protective processes. Rheumatic diseases are chronic conditions characterized by …