Sepsis is a multifactorial syndrome primarily determined by the host response to an invading
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …

In inflammation, extensive cell death may occur, which results in the release of chromatin
components into the extracellular environment. Individually, the purified chromatin …

Inter-α-trypsin inhibitor (IαI) family members are ancient and unique molecules that have
evolved over several hundred million years of vertebrate evolution. IαI is a complex …

Disseminated intravascular coagulation (DIC) is a heterogeneous group of disorders, which
manifest as a spectrum of haemorrhage and thrombosis complicating many primary …

Histones are known for their ability to bind to and regulate expression of DNA. However,
histones are also present in cytoplasm and extracellular fluids where they serve host …

Thrombo-inflammation describes the complex interplay between blood coagulation and
inflammation that plays a critical role in cardiovascular diseases. The third Maastricht …

Disseminated intravascular coagulation (DIC) is a syndrome triggered by infectious and
noninfectious pathologies characterized by excessive generation of thrombin within the …

The cell-based model of coagulation remains the basis of our current understanding of
clinical hemostasis and thrombosis. Its advancement on the coagulation cascade model has …

Histones are positively charged nuclear proteins that facilitate packaging of DNA into
nucleosomes common to all eukaryotic cells. Upon cell injury or cell signalling processes …

Objective: The endothelial glycocalyx (eGC) is a dynamic and multicomponent layer of
macromolecules found at the surface of vascular endothelium, which is largely …