Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

The synapse is the locus of plasticity where short-term alterations in synaptic strength are
converted to long-lasting memories. In addition to the presynaptic terminal and the …

All eukaryotic cells are composed of the cytoskeleton, which plays crucial roles in
coordinating diverse cellular functions such as cell division, morphology, migration …

The presence of atypical cytoskeletal dynamics, structures, and associated morphologies is
a common theme uniting numerous diseases and developmental disorders. In particular …

The development of new therapeutic avenues that target the early stages of Alzheimer's
disease (AD) is urgently necessary. A disintegrin and metalloproteinase domain 10 …

Abstract Asymptomatic Alzheimer's disease (AsymAD) describes the status of individuals
with preserved cognition but identifiable Alzheimer's disease (AD) brain pathology (ie, beta …

Cyclase-associated protein (CAP) has been discovered three decades ago in budding yeast
as a protein that associates with the cyclic adenosine monophosphate (cAMP)-producing …

Cyclase-associated protein (CAP) is an actin binding protein that has been initially
described as partner of the adenylyl cyclase in yeast. In all vertebrates and some …

Summary Protocadherin-19 (PCDH19) is a synaptic cell-adhesion molecule encoded by X-
linked PCDH19, a gene linked with epilepsy. Here, we report a synapse-to-nucleus …

Neurological diseases are among the leading causes of disability and death worldwide and
remain difficult to treat. Tissue engineering offers avenues to test potential treatments; …