Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

Melatonin is a fascinating molecule that has captured the imagination of many scientists
since its discovery in 1958. In recent times, the focus has changed from investigating its …

Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …

Oxidative stress (OS) has an important role in female reproduction, whether it is ovulation,
endometrium decidualization, menstruation, oocyte fertilization, or development …

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. In this context, tumor cells have an …

Simple Summary Several studies showed that oxidative stress is involved in cancer
occurrence, development, progression chemoresistance and radio resistance. The nuclear …

The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that
generates rhythmic changes in many physiological processes. Increasing evidence links …

Breast cancer is the most frequent malignant neoplasm in females. While conventional
treatments such as chemotherapy and radiotherapy are available, they are highly invasive …

The endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its
function can lead to various diseases. ER stress triggers an adaptive response called the …

Melatonin, a lipophilic hormone released from the pineal gland, has oncostatic effects on
various types of cancers. However, its cancer treatment potential needs to be improved by …