Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia

WN Lin, K Kapupara, YT Wen, YH Chen, IH Pan… - Marine drugs, 2020 - mdpi.com
Astaxanthin, a xanthophyll belonging to the family of carotenoids, is a potent antioxidant.
However, much less is known about its protective effects on the oxidative stress of ischemic …

The effects of two Nrf2 activators, bardoxolone methyl and omaveloxolone, on retinal ganglion cell survival during ischemic optic neuropathy

JY Chien, YY Chou, JW Ciou, FY Liu, SP Huang - Antioxidants, 2021 - mdpi.com
Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the most common acute
optic neuropathies that affect the over 55-year-old population. NAION causes the loss of …

Long term therapeutic effects of icariin‐loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP‐β/G‐CSF/noncanonical …

TD Desai, YT Wen, JR Daddam… - Bioengineering & …, 2022 - Wiley Online Library
An ischemic insult at optic nerve (ON) is followed by detrimental neuroinflammation that
results in progressive and long‐lasting retinal ganglion cell (RGC) death and vision loss …

Therapeutic effects of puerarin against anterior ischemic optic neuropathy through antiapoptotic and anti-inflammatory actions

MANN Le, YT Wen, YC Ho… - … & visual science, 2019 - iovs.arvojournals.org
Purpose: This study investigated the therapeutic effects of puerarin (PR) on a rat model of
anterior ischemic optic neuropathy (rAION). Methods: The neuroprotective effects of PR on …

Protective effects of Oroxylin A on retinal ganglion cells in experimental model of anterior ischemic optic neuropathy

JY Chien, SF Lin, YY Chou, CYF Huang, SP Huang - Antioxidants, 2021 - mdpi.com
Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute
vision loss in older people, and there is no effective therapy. The effect of the systemic or …

Neuroprotection and Neuroregeneration Strategies Using the rNAION Model: Theory, Histology, Problems, Results and Analytical Approaches

SL Bernstein, Y Guo, Z Mehrabian… - International journal of …, 2022 - mdpi.com
Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common cause of
sudden optic nerve (ON)-related vision loss in humans. Study of this disease has been …

Refining Flash Visual Evoked Potential Analysis in Rats: A Novel Approach Using Bilateral Epidural Electrodes

KM Woo, Y Guo, Z Mehrabian, NR Miller… - … Vision Science & …, 2024 - tvst.arvojournals.org
Purpose: Visual evoked potentials (VEPs) are electrical signals generated at the visual
cortex following visual stimulation. Flash VEPs (fVEPs) are produced by global retinal …

Biomarkers of lesion severity in a rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION)

Y Guo, Z Mehrabian, MA Johnson, NR Miller… - Plos one, 2021 - journals.plos.org
The rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION) is similar in
many of its pathophysiological responses to clinical NAION. Like human NAION, there is …

Early effects of cardiopulmonary bypass surgery on retinal nerve fiber layer and ganglion cell layer

CZ Fikret, E Simsek, NI Ucgun, E Kulahcioglu - … and Photodynamic Therapy, 2023 - Elsevier
Purpose To determine the effects of cardiopulmonary bypass surgery on retinal nerve fiber
layer, ganglion cell layer, and macula by optic coherens tomography (OCT). Method Sixty …

Restless Legs Syndrome and the Eyes: Spectral-Domain Optic Coherence Tomography Study

NC Usta, BO Gunay - The Neurologist, 2022 - journals.lww.com
Background: Restless legs syndrome (RLS) is a movement disorder thought to be caused by
impaired dopamine action. This study aimed to evaluate possible changes in ocular …