HIV-1 has evolved a plethora of strategies to overcome the cytoskeletal barrier (ie, actin and
intermediate filaments (AFs and IFs) and microtubules (MTs)) to achieve the viral cycle. HIV …

HIV-exposed seronegative individuals (HESIs) are a small fraction of persons who are
multiply exposed to human immunodeficiency virus (HIV), but do not exhibit serological or …

The transactive response DNA-binding protein (TARDBP/TDP-43) influences the processing
of diverse transcripts, including that of histone deacetylase 6 (HDAC6). Here, we assessed …

The transactive response DNA-binding protein (TARDBP/TDP-43) is known to stabilize the
anti-HIV-1 factor, histone deacetylase 6 (HDAC6). TDP-43 has been reported to determine …

In the absence of antiviral therapy, HIV-1 infection progresses to a wide spectrum of clinical
manifestations that are the result of an entangled contribution of host, immune and viral …

Although some individuals with HIV-2 develop severe immunodeficiency and AIDS-related
complications, most may never progress to AIDS. Replication-competent HIV-2 isolated from …

The presence of genetic mutations in HIV poses a significant challenge, potentially leading
to antiretroviral resistance and hampering therapeutic development. The Brazilian …

BACKGROUND Elite controllers (EC) are human immunodeficiency virus (HIV)-positive
individuals who can maintain low viral loads for extended periods without antiretroviral …

The extensive genetic diversity of HIV-1 represents a major challenge to public health
interventions, treatment, and successful vaccine design. This challenge is particularly …

Los virus emergentes y reemergentes causan brotes epidémicos que representan crisis
globales impactando en la salud de las personas y, por tanto, en el desarrollo económico …