Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …

Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …

Metastasis is the leading cause of cancer-related deaths. It is unclear how intratumor
heterogeneity (ITH) contributes to metastasis and how metastatic cells adapt to distant tissue …

Understanding the cell biological mechanisms that enable tumor cells to persist after therapy
is necessary to improve the treatment of recurrent disease. Here, we demonstrate that …

Introduction: The mitochondrial uniporter (MCU) Ca2+ ion channel represents the primary
means for Ca2+ uptake by mitochondria. Mitochondrial matrix Ca2+ plays critical roles in …

Differential expression of genes involved in certain processes is a collaborative outcome of
crosstalk between signalling molecules and epigenetic modifiers. In response to …

Activin A, a member of the transforming growth factor‑β (TGF‑β) superfamily, has been
implicated in the tumorigenesis and progression of various cancers. However, it remains …

Epithelial to Mesenchymal Transition (EMT) and its reverse—Mesenchymal to Epithelial
Transition (MET) are hallmarks of metastasis. Cancer cells use this reversible cellular …

Cellular plasticity is a well-known dynamic feature of tumor cells that endows tumors with
heterogeneity and therapeutic resistance and alters their invasion–metastasis progression …

Lethal prostate cancer (PCa) is characterized by the presence of metastases and
development of resistance to therapies. Metastases form in a multi-step process enabled by …