Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their
cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only …

Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are
commonly encountered in clinical practice and often have implications for cardiovascular …

Background Persistent chylomicronemia is a genetic recessive disorder that is classically
caused by familial chylomicronemia syndrome (FCS), but it also has multifactorial causes …

Lowering the levels of LDL cholesterol in the plasma has been shown to reduce the risk of
atherosclerotic cardiovascular disease (ASCVD). Several other lipoproteins, such as …

Hypertriglyceridemia, a commonly encountered phenotype in cardiovascular and metabolic
clinics, is surprisingly complex. A range of genetic variants, from single-nucleotide variants …

Multifactorial chylomicronemia syndrome (MCS or type V hyperlipoproteinemia) is the most
frequent cause of severe hypertriglyceridemia and is associated with an increased risk of …

Among the determinants of atherosclerotic cardiovascular disease (ASCVD), genetic and
experimental evidence has provided data on a major role of angiopoietin-like proteins 3 and …

Context The relative incidence of acute pancreatitis, ischemic cardiovascular disease, and
diabetes in hyperchylomicronemic patients exhibiting familial chylomicronemia syndrome …

Abstract Aims Apolipoprotein C-II (ApoC-II) is thought to activate lipoprotein lipase (LPL) and
is therefore a possible target for treating hypertriglyceridemia. Its relationship with …

Introduction Primary chylomicronemia is characterized by pathological accumulation of
chylomicrons in the plasma causing severe hypertriglyceridemia, typically> 10 mmol/L (> …