Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Molecular magnetic resonance imaging with Gd (III)-based contrast agents: challenges and key advances

H Li, TJ Meade - Journal of the American Chemical Society, 2019 - ACS Publications
In an era of personalized medicine, the clinical community has become increasingly focused
on understanding diseases at the cellular and molecular levels. Magnetic resonance …

Lanthanide probes for bioresponsive imaging

MC Heffern, LM Matosziuk, TJ Meade - Chemical reviews, 2014 - ACS Publications
The chemistry of the less familiar elements is a fascinating topic especially for the inorganic
minded. The lanthanides, or rare earths, comprise the 5d block of the periodic table and …

Microsatellite instability: diagnosis, heterogeneity, discordance, and clinical impact in colorectal cancer

C Evrard, G Tachon, V Randrian, L Karayan-Tapon… - Cancers, 2019 - mdpi.com
Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Classification and basic properties of contrast agents for magnetic resonance imaging

CFGC Geraldes, S Laurent - Contrast media & molecular …, 2009 - Wiley Online Library
A comprehensive classification of contrast agents currently used or under development for
magnetic resonance imaging (MRI) is presented. Agents based on small chelates …

Alternatives to gadolinium-based metal chelates for magnetic resonance imaging

S Viswanathan, Z Kovacs, KN Green… - Chemical …, 2010 - ACS Publications
Magnetic resonance imaging (MRI) has been immensely valuable in diagnostic clinical
imaging over the last few decades owing to its exceptional spatial and anatomical …

Biomedical applications of macrocyclic ligand complexes

RE Mewis, SJ Archibald - Coordination Chemistry Reviews, 2010 - Elsevier
Macrocyclic chelators can form highly stable complexes with transition metals and
lanthanides. In this review, the recent advances towards biomedical applications of …

Gadolinium (III) complexes as MRI contrast agents: ligand design and properties of the complexes

P Hermann, J Kotek, V Kubíček, I Lukeš - Dalton Transactions, 2008 - pubs.rsc.org
Magnetic resonance imaging is a commonly used diagnostic method in medicinal practice
as well as in biological and preclinical research. Contrast agents (CAs), which are often …

Applications for transition-metal chemistry in contrast-enhanced magnetic resonance imaging

A Gupta, P Caravan, WS Price… - Inorganic …, 2020 - ACS Publications
Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …

Chemical exchange saturation transfer contrast agents for magnetic resonance imaging

AD Sherry, M Woods - Annu. Rev. Biomed. Eng., 2008 - annualreviews.org
Magnetic resonance imaging (MRI) contrast agents have become an important tool in
clinical medicine. The most common agents are Gd3+-based complexes that shorten bulk …