[PDF][PDF] Research progress on ferroptosis and its role in epilepsy.

X Liu, J Chen - Journal of Physiology & Pharmacology, 2022 - jpp.krakow.pl
Epilepsy is a disease characterized by central nervous system dysfunction induced by an
excessive synchronous discharge of cerebral neurons, with diverse etiologies and …

[HTML][HTML] Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression …

S Javaid, F Alqahtani, W Ashraf, SMM Anjum… - Biomedicine & …, 2023 - Elsevier
Abstract Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic
signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic …

Long-Term Supplementation of Syzygium cumini (L.) Skeels Concentrate Alleviates Age-Related Cognitive Deficit and Oxidative Damage: A Comparative Study of …

N Malik, S Javaid, W Ashraf, F Siddique, MF Rasool… - Nutrients, 2023 - mdpi.com
The Syzygium cumini (L.) Skeels is reported to have medicinal properties, but its benefits on
age-related neurological changes have not been previously explored. In the current study …

[HTML][HTML] Unveiling the potential of perampanel and pregabalin in addressing pentylenetetrazole-induced electrographic alterations and neurobehavioral anomalies

M Tariq, S Javaid, W Ashraf, SMM Anjum… - Biomedicine & …, 2024 - Elsevier
Chemical kindling is broadly used experimental model to investigate novel treatments on the
process of epileptogenesis and coexisting behavioral comorbidities. The current study …

[HTML][HTML] Combination of levetiracetam with sodium selenite prevents pentylenetetrazole-induced kindling and behavioral comorbidities in rats

Z Rehman, T Farooq, S Javaid, W Ashraf… - Saudi Pharmaceutical …, 2022 - Elsevier
Introduction The pentylenetetrazol (PTZ)-induced kindling model acts through the
antagonism of central GABA A receptors and is one of the most widely used experimental …

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats

U Javaid, S Javaid, W Ashraf, MF Rasool… - Dose …, 2021 - journals.sagepub.com
The current study was planned to investigate the pharmacological basis of Solanum
virginianum extract (SV. CR) pertaining to anxiolytic, antidepressant and memory-enhancing …

[PDF][PDF] Evaluation of ivermectin and vitamin E based combination with antiseizure rufinamide drug for mitigation of pentylenetetrazole-induced kindling, behavioral …

A Sabir, S Tehreem, M Farooq, W Ashraf… - Journal of Physiology …, 2024 - researchgate.net
Pentylenetetrazole-(PTZ)-induced kindling is a broadly used experimental model to evaluate
the impact of antiseizure drugs and their novel combination on seizure progression. The …

Demaghi, a polyherbal formulation, mitigates aluminum chloride-induced neurological impairment in mice: Insights from phytochemical analysis and behavioral …

H Ali, H Usman, W Ashraf, F Alqahtani, S Javaid… - Heliyon, 2023 - cell.com
Herbal products have been very popular in Pakistan for their curative significance against
various disorders. Demaghi (DEMG) is a widely used herbal product claimed to own natural …

An Atlas of the Quantitative Protein Expression of Anti-Epileptic-Drug Transporters, Metabolizing Enzymes and Tight Junctions at the Blood–Brain Barrier in Epileptic …

R Sato, K Ohmori, M Umetsu, M Takao, M Tano… - Pharmaceutics, 2021 - mdpi.com
The purpose of the present study was to quantitatively elucidate the levels of protein
expression of anti-epileptic-drug (AED) transporters, metabolizing enzymes and tight …

[HTML][HTML] Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's …

N Rasheed, HK Hussain, Z Rehman, A Sabir… - Experimental …, 2025 - Elsevier
Abstract Aluminum chloride (AlCl 3), a known neurotoxic and Alzheimerogenic metal
disrupts redox homeostasis which plays a pivotal role in pathophysiology of …