The future of early cancer detection

RC Fitzgerald, AC Antoniou, L Fruk, N Rosenfeld - Nature medicine, 2022 - nature.com
A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection …

Challenges and opportunities for developing more generalizable polygenic risk scores

Y Wang, K Tsuo, M Kanai, BM Neale… - Annual review of …, 2022 - annualreviews.org
Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …

The impact of the Covid-19 pandemic on breast cancer early detection and screening

JD Figueroa, E Gray, N Pashayan, S Deandrea… - Preventive …, 2021 - Elsevier
The COVID-19 pandemic affects mortality and morbidity, with disruptions expected to
continue for some time, with access to timely cancer-related services a concern. For breast …

[HTML][HTML] The current status of risk-stratified breast screening

AK Clift, D Dodwell, S Lord, S Petrou, SM Brady… - British journal of …, 2022 - nature.com
Apart from high-risk scenarios such as the presence of highly penetrant genetic mutations,
breast screening typically comprises mammography or tomosynthesis strategies defined by …

[HTML][HTML] Artificial intelligence in mammographic phenotyping of breast cancer risk: a narrative review

A Gastounioti, S Desai, VS Ahluwalia, EF Conant… - Breast Cancer …, 2022 - Springer
Background Improved breast cancer risk assessment models are needed to enable
personalized screening strategies that achieve better harm-to-benefit ratio based on earlier …

Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study

X Yang, M Eriksson, K Czene, A Lee, G Leslie… - Journal of medical …, 2022 - jmg.bmj.com
Background The multifactorial Breast and Ovarian Analysis of Disease Incidence and
Carrier Estimation Algorithm (BOADICEA) breast cancer risk prediction model has been …

Comparison of mammography AI algorithms with a clinical risk model for 5-year breast cancer risk prediction: an observational study

VA Arasu, LA Habel, NS Achacoso, DSM Buist… - Radiology, 2023 - pubs.rsna.org
Background Although several clinical breast cancer risk models are used to guide screening
and prevention, they have only moderate discrimination. Purpose To compare selected …

[HTML][HTML] Personalized risk assessment for prevention and early detection of breast cancer: integration and implementation (PERSPECTIVE I&I)

JD Brooks, H Nabi, IL Andrulis, AC Antoniou… - Journal of personalized …, 2021 - mdpi.com
Early detection of breast cancer through screening reduces breast cancer mortality. The
benefits of screening must also be considered within the context of potential harms (eg, false …

[HTML][HTML] Smart textiles for self-powered biomonitoring

J Yin, S Wang, A Di Carlo, A Chang, X Wan, J Xu… - Med-X, 2023 - Springer
Merging electronics with textiles has become an emerging trend since textiles hold
magnificent wearing comfort and user-friendliness compared with conventional wearable …

[HTML][HTML] Study protocol comparing the ethical, psychological and socio-economic impact of personalised breast cancer screening to that of standard screening in the “ …

A Roux, R Cholerton, J Sicsic, N Moumjid, DP French… - BMC cancer, 2022 - Springer
Abstract Background The MyPeBS study is an ongoing randomised controlled trial testing
whether a risk-stratified breast cancer screening strategy is non-inferior, or eventually …