Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Structural and functional brain alterations are common in patients with major depressive
disorder (MDD). In this review, we assessed the recent literature (1995–2018) on the …

This chapter sets out the current status of the evidence-base for the efficacy and
effectiveness of psychological therapies. First, methods for eliciting and synthesizing …

Depression is classified as one of the most common mental disorders. Its prevalence has
recently increased, becoming a growing public health threat. This review focuses on …

Rationale Suicidality is a major public health concern with limited treatment options.
Accordingly, there is a need for innovative interventions for suicidality. Preliminary evidence …

Background Mental illness is a leading cause of the global burden of disease. Physical
activity (PA) can improve physical and mental health outcomes for people with mental …

COVID-19 was declared a global pandemic by the World Health Organization on March 11,
2020. The COVID-19 pandemic and resulting social disruption has left many to struggle with …

Objectives As clinical practice guidelines vary widely in their search strategies and
recommendations of complementary and alternative medicine (CAM) for depression, this …

Emotional blunting is frequently reported by patients with major depressive disorder (MDD)
and has been identified as one of the most prominent side effects of antidepressants leading …

Objectives Despite the available therapies for treatment-resistant depression (TRD), there
are a limited number that are evidence-based and effective in this hard-to-treat population …