Rafting down the metastatic cascade: the role of lipid rafts in cancer metastasis, cell death, and clinical outcomes

JD Greenlee, T Subramanian, K Liu, MR King - Cancer research, 2021 - AACR
Lipid rafts are tightly packed, cholesterol-and sphingolipid-enriched microdomains within the
plasma membrane that play important roles in many pathophysiologic processes. Rafts have …

Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma

Y Kang, W He, C Ren, J Qiao, Q Guo, J Hu… - Signal transduction and …, 2020 - nature.com
Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck
region which mainly distributes in southern China and Southeast Asia and has a crucial …

Akt-ing up just about everywhere: compartment-specific Akt activation and function in receptor tyrosine kinase signaling

MG Sugiyama, GD Fairn, CN Antonescu - Frontiers in Cell and …, 2019 - frontiersin.org
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

MicroRNA‐351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus

SH Chen, XN Liu, Y Peng - Journal of cellular and molecular …, 2019 - Wiley Online Library
Gestational diabetes mellitus (GDM) is known as different degree glucose intolerance that is
initially identified during pregnancy. MicroRNAs (miRs) may be a potential candidate for …

Flotillins: At the Intersection of Protein S-Palmitoylation and Lipid-Mediated Signaling

K Kwiatkowska, OV Matveichuk, J Fronk… - International Journal of …, 2020 - mdpi.com
Flotillin-1 and flotillin-2 are ubiquitously expressed, membrane-associated proteins involved
in multifarious cellular events from cell signaling, endocytosis, and protein trafficking to gene …

Flotillin membrane domains in cancer

C Gauthier-Rouvière, S Bodin, F Comunale… - Cancer and Metastasis …, 2020 - Springer
Flotillins 1 and 2 are two ubiquitous, highly conserved homologous proteins that assemble
to form heterotetramers at the cytoplasmic face of the plasma membrane in cholesterol-and …

Precision medicine in nasopharyngeal carcinoma: comprehensive review of past, present, and future prospect

PY Siak, WS Heng, SSH Teoh, YY Lwin… - Journal of Translational …, 2023 - Springer
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with high propensity for
lymphatic spread and distant metastasis. It is prominent as an endemic malignancy in …

[HTML][HTML] ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway

S Li, H Liu, W Liu, N Shi, M Zhao… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The mechanisms of self-renewal and pluripotency maintenance of human pluripotent stem
cells (hPSCs) have not been fully elucidated, especially for the role of those poorly …

Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract

S Sur, H Nakanishi, C Flaveny, JE Ippolito… - Cell Communication and …, 2019 - Springer
Background Metabolic reprogramming is one of the hallmarks of cancer which favours rapid
energy production, biosynthetic capabilities and therapy resistance. In our previous study …

MicroRNA-485-5p suppresses the proliferation, migration and invasion of small cell lung cancer cells by targeting flotillin-2

F Gao, H Wu, R Wang, Y Guo, Z Zhang, T Wang… - …, 2019 - Taylor & Francis
This study is aimed to elucidate the mechanisms underlying the role of miR-485-5p in small
cell lung cancer (SCLC). The expression of miR-485-5p were quantified with real time …