Rafting down the metastatic cascade: the role of lipid rafts in cancer metastasis, cell death, and clinical outcomes
Lipid rafts are tightly packed, cholesterol-and sphingolipid-enriched microdomains within the
plasma membrane that play important roles in many pathophysiologic processes. Rafts have …
plasma membrane that play important roles in many pathophysiologic processes. Rafts have …
Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma
Y Kang, W He, C Ren, J Qiao, Q Guo, J Hu… - Signal transduction and …, 2020 - nature.com
Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck
region which mainly distributes in southern China and Southeast Asia and has a crucial …
region which mainly distributes in southern China and Southeast Asia and has a crucial …
Akt-ing up just about everywhere: compartment-specific Akt activation and function in receptor tyrosine kinase signaling
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
MicroRNA‐351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus
SH Chen, XN Liu, Y Peng - Journal of cellular and molecular …, 2019 - Wiley Online Library
Gestational diabetes mellitus (GDM) is known as different degree glucose intolerance that is
initially identified during pregnancy. MicroRNAs (miRs) may be a potential candidate for …
initially identified during pregnancy. MicroRNAs (miRs) may be a potential candidate for …
Flotillins: At the Intersection of Protein S-Palmitoylation and Lipid-Mediated Signaling
K Kwiatkowska, OV Matveichuk, J Fronk… - International Journal of …, 2020 - mdpi.com
Flotillin-1 and flotillin-2 are ubiquitously expressed, membrane-associated proteins involved
in multifarious cellular events from cell signaling, endocytosis, and protein trafficking to gene …
in multifarious cellular events from cell signaling, endocytosis, and protein trafficking to gene …
Flotillin membrane domains in cancer
C Gauthier-Rouvière, S Bodin, F Comunale… - Cancer and Metastasis …, 2020 - Springer
Flotillins 1 and 2 are two ubiquitous, highly conserved homologous proteins that assemble
to form heterotetramers at the cytoplasmic face of the plasma membrane in cholesterol-and …
to form heterotetramers at the cytoplasmic face of the plasma membrane in cholesterol-and …
Precision medicine in nasopharyngeal carcinoma: comprehensive review of past, present, and future prospect
PY Siak, WS Heng, SSH Teoh, YY Lwin… - Journal of Translational …, 2023 - Springer
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with high propensity for
lymphatic spread and distant metastasis. It is prominent as an endemic malignancy in …
lymphatic spread and distant metastasis. It is prominent as an endemic malignancy in …
[HTML][HTML] ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway
S Li, H Liu, W Liu, N Shi, M Zhao… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The mechanisms of self-renewal and pluripotency maintenance of human pluripotent stem
cells (hPSCs) have not been fully elucidated, especially for the role of those poorly …
cells (hPSCs) have not been fully elucidated, especially for the role of those poorly …
Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract
Background Metabolic reprogramming is one of the hallmarks of cancer which favours rapid
energy production, biosynthetic capabilities and therapy resistance. In our previous study …
energy production, biosynthetic capabilities and therapy resistance. In our previous study …
MicroRNA-485-5p suppresses the proliferation, migration and invasion of small cell lung cancer cells by targeting flotillin-2
F Gao, H Wu, R Wang, Y Guo, Z Zhang, T Wang… - …, 2019 - Taylor & Francis
This study is aimed to elucidate the mechanisms underlying the role of miR-485-5p in small
cell lung cancer (SCLC). The expression of miR-485-5p were quantified with real time …
cell lung cancer (SCLC). The expression of miR-485-5p were quantified with real time …