Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …

Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …

Abstract Transglutaminase 2 (TG2) plays a vital role in stabilizing extracellular matrix (ECM)
proteins through enzymatic crosslinking during tissue growth, repair, and inflammation. TG2 …

Abstract Serotonin (5-hydroxytryptamine, 5-HT) metabolism has long been linked to
tumorigenesis and tumor progression. Numerous studies have shown the functions of 5-HT …

Cerebral cavernous malformations (CCM) are manifested by microvascular lesions
characterized by leaky endothelial cells with minimal intervening parenchyma …

Transglutaminase 2 (TG2) has emerged as a key cancer cell survival factor that drives
epithelial to mesenchymal transition, angiogenesis, metastasis, inflammation, drug …

Tissue transglutaminase (transglutaminase type 2; TG2) is the most ubiquitously expressed
member of the transglutaminase family (EC 2.3. 2.13) that catalyzes specific post …

Biophysical properties of extracellular matrix (ECM), such as matrix stiffness, viscoelasticity
and matrix fibrous structure, are emerging as important factors that regulate progression of …

Simple Summary The physical properties of a tumor, such as stiffness, are important drivers
of tumor progression. However, current in vitro tumor models fail to recapitulate the full range …