Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

O Gires, M Pan, H Schinke, M Canis… - Cancer and Metastasis …, 2020 - Springer
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …

[HTML][HTML] EpCAM: structure and function in health and disease

U Schnell, V Cirulli, BNG Giepmans - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Injection of tumor cells in mice more than 30years ago resulted in the discovery of an
epithelial antigen, later defined as a cell adhesion molecule (EpCAM). Although EpCAM has …

[HTML][HTML] Skin cells undergo asynthetic fission to expand body surfaces in zebrafish

KY Chan, CCS Yan, HY Roan, SC Hsu, TL Tseng… - Nature, 2022 - nature.com
As an animal's surface area expands during development, skin cell populations must quickly
respond to maintain sufficient epithelial coverage. Despite much progress in understanding …

[HTML][HTML] Cell intercalation from top to bottom

E Walck-Shannon, J Hardin - Nature reviews Molecular cell biology, 2014 - nature.com
Animal development requires a carefully orchestrated cascade of cell fate specification
events and cellular movements. A surprisingly small number of choreographed cellular …

Mechanisms of otoconia and otolith development

YW Lundberg, Y Xu, KD Thiessen… - Developmental …, 2015 - Wiley Online Library
Background: Otoconia are bio‐crystals that couple mechanic forces to the sensory hair cells
in the utricle and saccule, a process essential for us to sense linear acceleration and gravity …

Functional implications of the dynamic regulation of EpCAM during epithelial-to-mesenchymal transition

TC Brown, NV Sankpal, WE Gillanders - Biomolecules, 2021 - mdpi.com
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in
epithelial tissues. EpCAM forms intercellular, homophilic adhesions, modulates epithelial …

Functions of EpCAM in physiological processes and diseases

L Huang, Y Yang, F Yang, S Liu… - International …, 2018 - spandidos-publications.com
EpCAM (epithelial cell adhesion molecule) is a type I transmembrane glycoprotein, which
was originally identified as a tumor‑associated antigen due to its high expression level in …

EpCAM and the biology of hepatic stem/progenitor cells

L Dollé, ND Theise, E Schmelzer… - American Journal …, 2015 - journals.physiology.org
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is
frequently and highly expressed on carcinomas, tumor-initiating cells, selected tissue …

Re-epithelialization of cutaneous wounds in adult zebrafish combines mechanisms of wound closure in embryonic and adult mammals

R Richardson, M Metzger, P Knyphausen… - …, 2016 - journals.biologists.com
Re-epithelialization of cutaneous wounds in adult mammals takes days to complete and
relies on numerous signalling cues and multiple overlapping cellular processes that take …

[HTML][HTML] EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development

H Lu, J Ma, Y Yang, W Shi, L Luo - Developmental Cell, 2013 - cell.com
Mechanisms underlying cell-type-specific response to morphogens or signaling molecules
during embryonic development are poorly understood. To learn how response to the liver …