Modeling developmental brain diseases using human pluripotent stem cells-derived brain organoids–progress and perspective

A Bhattacharya, WWY Choi, J Muffat, Y Li - Journal of Molecular Biology, 2022 - Elsevier
Developmental brain diseases encompass a group of conditions resulting from genetic or
environmental perturbations during early development. Despite the increased research …

Involvement of vascular endothelial growth factor in schizophrenia

A Rampino, T Annese, S Torretta, R Tamma… - Neuroscience …, 2021 - Elsevier
Vascular endothelial growth factor (VEGF), which acts as an angiogenic and neurotrophic
factor, is involved the regulation of cerebral blood volume and flow in Schizophrenia (SCZ) …

Honokiol improves depression-like behaviors in rats by HIF-1α-VEGF signaling pathway activation

XX Fan, WY Sun, Y Li, Q Tang, LN Li, X Yu… - Frontiers in …, 2022 - frontiersin.org
Increasing evidence indicates that the pathogenesis of depression is closely linked to
impairments in neuronal synaptic plasticity. Honokiol, a biologically active substance …

Correlation of BDNF, VEGF, TNF‐α, and S100B with cognitive impairments in chronic, medicated schizophrenia patients

P Chukaew, N Bunmak, N Auampradit… - …, 2022 - Wiley Online Library
Cognitive impairment is a prominent cause of disability in schizophrenia. Although
antipsychotic drugs can rescue the psychotic symptoms, the cognitive impairments persist …

Overdispersed gene expression in schizophrenia

G Huang, D Osorio, J Guan, G Ji, JJ Cai - npj Schizophrenia, 2020 - nature.com
Schizophrenia (SCZ) is a severe, highly heterogeneous psychiatric disorder with varied
clinical presentations. The polygenic genetic architecture of SCZ makes identification of …

Preventive and therapeutic effects of environmental enrichment in Wistar rats submitted to neonatal hypoxia-ischemia

LE Durán-Carabali, DM Arcego, EF Sanches… - Behavioural brain …, 2019 - Elsevier
Environmental enrichment (EE) at early stages of neurodevelopment attenuates HI-induced
behavioral, histological and cellular damage. However, the effects of EE exposure during …

Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental …

KR Howell, AJ Law - Schizophrenia research, 2020 - Elsevier
Normative brain development is contingent on the complex interplay between genes and
environment. Schizophrenia (SCZ) is considered a highly polygenic, neurodevelopmental …

It takes two to tango: Widening our understanding of the onset of schizophrenia from a neuro-angiogenic perspective

BS Casas, D Arancibia-Altamirano… - Frontiers in Cell and …, 2022 - frontiersin.org
Schizophrenia is a chronic debilitating mental disorder characterized by perturbations in
thinking, perception, and behavior, along with brain connectivity deficiencies …

Translational control in neurovascular brain development

K Chalkiadaki, E Statoulla… - Royal Society …, 2021 - royalsocietypublishing.org
The human brain carries out complex tasks and higher functions and is crucial for
organismal survival, as it senses both intrinsic and extrinsic environments. Proper brain …

Blood biomarkers for neonatal hypoxic–ischemic encephalopathy in the presence and absence of sentinel events

EK Broni, AC Eke, D Vaidya, X Tao… - Journal of …, 2021 - nature.com
Objective To determine if neonatal serum biomarkers representing different pathways of
injury differ for cases of HIE of unknown cause to gain insight into timing and mechanism of …