Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for
rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is …

Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of
PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential …

Epilepsy is a chronic neurological disorder characterized by irregular, excessive neuronal
excitability, and recurrent seizures that affect millions of patients worldwide. Currently …

Objective The study objective was to determine the protective effects of thymoquinone (TQ)
on brain tissues oxidative stress status, hippocampal cytokine level, and learning and …

Objective The effects of aminoguanidine (AG) were investigated in a rat model of
lipopolysaccharide (LPS)-induced anxiety-and depression-like behaviors. Materials and …

Objective (s): The aim of current study was to evaluate improving effects of pioglitazone as
an agonist of peroxisome proliferator-activated receptor gamma (PPARγ), on brain-derived …

Epilepsy is one of the furthermost common neurodegenerative diseases affecting above 50
million individuals worldwide. The pathogenesis of epileptic seizures is not satisfactorily …

Oxidative stress is one of the main pathogenic factors of neuron damage in
neurodegenerative processes; this makes it an important therapeutic target to which the …

Background Cisplatin (CP) is a common antineoplastic agent widely used to treat a broad
spectrum of cancers. However, its usage for cancer treatment was restricted due to various …

Black seed (Nigella sativa) oil has been used in various dermatological applications, and its
major constituent, thymoquinone (TQ) has been shown to exhibit antiproliferative activity …