Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Production of polyunsaturated fatty acids by Schizochytrium (Aurantiochytrium) spp.

G Chi, Y Xu, X Cao, Z Li, M Cao, Y Chisti, N He - Biotechnology advances, 2022 - Elsevier
Diverse health benefits are associated with dietary consumption of omega-3 long-chain
polyunsaturated fatty acids (ω-3 LC-PUFA), particularly docosahexaenoic acid (DHA) and …

A guide to metabolic flux analysis in metabolic engineering: Methods, tools and applications

MR Antoniewicz - Metabolic engineering, 2021 - Elsevier
The field of metabolic engineering is primarily concerned with improving the biological
production of value-added chemicals, fuels and pharmaceuticals through the design …

Metabolic engineering in the host Yarrowia lipolytica

AM Abdel-Mawgoud, KA Markham, CM Palmer… - Metabolic …, 2018 - Elsevier
The nonconventional, oleaginous yeast, Yarrowia lipolytica is rapidly emerging as a
valuable host for the production of a variety of both lipid and nonlipid chemical products …

Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity

Z Luo, N Liu, Z Lazar, A Chatzivasileiou, V Ward… - Metabolic …, 2020 - Elsevier
The abundant supply of biosynthetic precursors and product compatibility with the
intracellular environment play important roles for microbial isoprenoid production. In this …

[HTML][HTML] Oleaginous yeasts as cell factories for the sustainable production of microbial lipids by the valorization of agri-food wastes

A Caporusso, A Capece, I De Bari - Fermentation, 2021 - mdpi.com
The agri-food industry annually produces huge amounts of crops residues and wastes, the
suitable management of these products is important to increase the sustainability of agro …

Metabolic engineering of Yarrowia lipolytica for high-level production of scutellarin

P Zhang, W Wei, Y Shang, BC Ye - Bioresource Technology, 2023 - Elsevier
Scutellarin drugs have been recognized as a key item in the national development of
essential clinical emergency drugs for treating cardiovascular and cerebrovascular …

Microbial chassis engineering drives heterologous production of complex secondary metabolites

J Liu, X Wang, G Dai, Y Zhang, X Bian - Biotechnology Advances, 2022 - Elsevier
The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …

Holistic approaches in lipid production by Yarrowia lipolytica

Z Lazar, N Liu, G Stephanopoulos - Trends in biotechnology, 2018 - cell.com
Concerns about climate change have driven research on the production of lipid-derived
biofuels as an alternative and renewable liquid fuel source. Using oleaginous yeasts for lipid …

Oleaginous yeast for biofuel and oleochemical production

M Spagnuolo, A Yaguchi, M Blenner - Current Opinion in Biotechnology, 2019 - Elsevier
Highlights•The yeasts, Cutaneotrichosporon oleaginosus, Lipomyces starkeyi, and
Rhodosporidium toruloides, grow on a wide range of substrates and naturally outperform …