G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering
intracellular signaling through coupling with G proteins and arrestins. Recent breakthroughs …

G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in
a wide range of physiological functions and in a large number of Food and Drug …

Arrestin proteins bind to active, phosphorylated G-protein-coupled receptors (GPCRs),
thereby preventing G-protein coupling, triggering receptor internalization and affecting …

Despite intense interest in discovering drugs that cause G-protein-coupled receptors
(GPCRs) to selectively stimulate or block arrestin signalling, the structural mechanism of …

Agonist-induced GPCR phosphorylation is a key determinant for the binding and activation
of β-arrestins (βarrs). However, it is not entirely clear how different GPCRs harboring …

Abstract β-arrestins are critical regulator and transducer proteins for G-protein-coupled
receptors (GPCRs). β-arrestin is widely believed to be activated by forming a stable and …

Summary β-arrestins bind G protein-coupled receptors to terminate G protein signaling and
to facilitate other downstream signaling pathways. Using single-molecule fluorescence …

Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the
G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution …

G protein–coupled receptor (GPCR) kinases (GRKs) and arrestins interact with agonist-
bound GPCRs to promote receptor desensitization and downregulation. They also trigger …

Arrestins were initially identified for their role in homologous desensitization and
internalization of G protein–coupled receptors. Receptor-bound arrestins also initiate …