Executive summary Despite substantial progress in reducing the global impact of many non-
communicable diseases, including heart disease and cancer, morbidity and mortality due to …

Background Seasonal influenza virus is a common cause of acute lower respiratory infection
(ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated …

Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …

Background Human metapneumovirus is a common virus associated with acute lower
respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs …

Background Human parainfluenza virus (hPIV) is a common virus in childhood acute lower
respiratory infections (ALRI). However, no estimates have been made to quantify the global …

Respiratory syncytial virus (RSV) is an enveloped RNA virus which is responsible for
approximately 80% of lower respiratory tract infections in children. Current lines of evidence …

Background Respiratory viral infections are a major cause of morbidity and hospitalization in
young children. Nevertheless, the population burden of respiratory viral infections …

Background Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of
respiratory viruses on the development of airway disease is poorly understood. Methods …

Background Noninfluenza respiratory viruses are responsible for a substantial burden of
disease in the United States. Household transmission is thought to contribute significantly to …

Respiratory syncytial virus (RSV) is the most common virus identified in children hospitalised
with acute respiratory infections. However, less is known about RSV in community settings …