Epidermal growth factor, from gene organization to bedside

F Zeng, RC Harris - Seminars in cell & developmental biology, 2014 - Elsevier
In 1962, epidermal growth factor (EGF) was discovered by Dr. Stanley Cohen while studying
nerve growth factor (NGF). It was soon recognized that EGF is the prototypical member of a …

Mesenchymal stem/stromal cells in regenerative medicine: can preconditioning strategies improve therapeutic efficacy

R Schäfer, G Spohn, PC Baer - Transfusion Medicine and Hemotherapy, 2016 - karger.com
Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the
development of cell therapeutics in regenerative medicine. Featuring immunomodulatory …

Regulation of the alveolar regenerative niche by amphiregulin-producing regulatory T cells

KA Kaiser, LF Loffredo, K Santos-Alexis… - Journal of Experimental …, 2022 - rupress.org
Following respiratory viral infection, regeneration of the epithelial barrier is required to
preserve lung function and prevent secondary infections. Lung regulatory T (Treg) cells are …

Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis

TM Savage, KT Fortson, K de Los Santos-Alexis… - Immunity, 2024 - cell.com
Production of amphiregulin (Areg) by regulatory T (Treg) cells promotes repair after acute
tissue injury. Here, we examined the function of Treg cells in non-alcoholic steatohepatitis …

Mechanisms of tumor escape from immune system: role of mesenchymal stromal cells

A Poggi, A Musso, I Dapino, MR Zocchi - Immunology letters, 2014 - Elsevier
Tumor microenvironment represents the site where the tumor tries to survive and escape
from immune system-mediated recognition. Indeed, to proliferate tumor cells can divert the …

Chronic myelogenous leukaemia exosomes modulate bone marrow microenvironment through activation of epidermal growth factor receptor

C Corrado, L Saieva, S Raimondo… - Journal of cellular …, 2016 - Wiley Online Library
Chronic myelogenous leukaemia (CML) is a clonal myeloproliferative disorder. Recent
evidence indicates that altered crosstalk between CML and mesenchymal stromal cells may …

[HTML][HTML] Transdifferentiation of adipose-derived stem cells into keratinocyte-like cells: engineering a stratified epidermis

C Chavez-Munoz, KT Nguyen, W Xu, SJ Hong… - PloS one, 2013 - journals.plos.org
Skin regeneration is an important area of research in the field of tissue-engineering,
especially for cases involving loss of massive areas of skin, where current treatments are not …

[HTML][HTML] Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism

I Louradour, A Sharma, I Morin-Poulard, M Letourneau… - Elife, 2017 - elifesciences.org
Hematopoietic stem/progenitor cells in the adult mammalian bone marrow ensure blood cell
renewal. Their cellular microenvironment, called 'niche', regulates hematopoiesis both under …

Human placenta‐derived mesenchymal stem cells ameliorate diabetic kidney disease by modulating the T helper 17 cell/regulatory T‐cell balance through the …

J Wang, H Liu, G Yue, Y Deng… - Diabetes, Obesity and …, 2024 - Wiley Online Library
Aim To investigate the therapeutic effects and immunomodulatory mechanisms of human
placenta‐derived mesenchymal stem cells (PMSCs) in diabetic kidney disease (DKD) …

[HTML][HTML] Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer

L Song, MA Smith, P Doshi, K Sasser, W Fulp… - Journal of Thoracic …, 2014 - Elsevier
Introduction: Interleukin-6 (IL-6) can activate downstream signaling pathways in lung cancer
cells, such as the STAT3 pathway, and is reported to be produced by tumor cells with …