Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments
L Menéndez-Arias - Antiviral research, 2013 - Elsevier
The introduction of potent combination therapies in the mid-90s had a tremendous effect on
AIDS mortality. However, drug resistance has been a major factor contributing to …
AIDS mortality. However, drug resistance has been a major factor contributing to …
The EuroSIDA study: 25 years of scientific achievements
K Laut, O Kirk, J Rockstroh, A Phillips… - HIV …, 2020 - Wiley Online Library
The EuroSIDA study was initiated in 1994 and follows adult people living with HIV (PLHIV) in
100 collaborating clinics across 35 countries covering all European regions, Israel and …
100 collaborating clinics across 35 countries covering all European regions, Israel and …
Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance …
GL Melikian, SY Rhee, V Varghese… - Journal of …, 2014 - academic.oup.com
Objectives The introduction of two new non-nucleoside reverse transcriptase inhibitors
(NNRTIs) in the past 5 years and the identification of novel NNRTI-associated mutations …
(NNRTIs) in the past 5 years and the identification of novel NNRTI-associated mutations …
[HTML][HTML] Novel RNase H inhibitors blocking RNA-directed strand displacement DNA synthesis by HIV-1 reverse transcriptase
S Martín-Alonso, D Kang, JM Del Río… - Journal of molecular …, 2022 - Elsevier
In retroviruses, strand displacement DNA-dependent DNA polymerization catalyzed by the
viral reverse transcriptase (RT) is required to synthesize double-stranded proviral DNA. In …
viral reverse transcriptase (RT) is required to synthesize double-stranded proviral DNA. In …
HIV-1 reverse transcriptase connection subdomain mutations involved in resistance to approved non-nucleoside inhibitors
L Menéndez-Arias, G Betancor, T Matamoros - Antiviral research, 2011 - Elsevier
The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is a major
target of antiretroviral intervention. Non-nucleoside RT inhibitors (NNRTIs) bind to a …
target of antiretroviral intervention. Non-nucleoside RT inhibitors (NNRTIs) bind to a …
Characterization of HIV-1 near full-length proviral genome quasispecies from patients with undetectable viral load undergoing first-line HAART therapy
BM Alves, JD Siqueira, MM Garrido, OM Botelho… - Viruses, 2017 - mdpi.com
Increased access to highly active antiretroviral therapy (HAART) by human
immunodeficiency virus postive (HIV+) individuals has become a reality worldwide. In Brazil …
immunodeficiency virus postive (HIV+) individuals has become a reality worldwide. In Brazil …
Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis
Abstract HIV-1 reverse transcriptase (RT) connection subdomain mutations at positions 348,
369 and 376 have been associated with resistance to non-nucleoside RT inhibitors …
369 and 376 have been associated with resistance to non-nucleoside RT inhibitors …
Frequent cross-resistance to dapivirine in HIV-1 subtype C-infected individuals after first-line antiretroviral therapy failure in South Africa
KJ Penrose, CL Wallis, CJ Brumme… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
ABSTRACT A vaginal ring containing dapivirine (DPV) has shown moderate protective
efficacy against HIV-1 acquisition, but the activity of DPV against efavirenz (EFV)-and …
efficacy against HIV-1 acquisition, but the activity of DPV against efavirenz (EFV)-and …
Evaluation of HIV-1 antiretroviral drug resistance profiles in the peripheral blood reservoir of successfully treated persons using massive sequencing and viral full …
OM Botelho, RP Basso, LD Da Mota… - Journal of …, 2023 - academic.oup.com
Background Antiretroviral therapy has revolutionized HIV treatment, increasing quality and
life expectancy of people living with HIV (PLWH). However, the expansion of treatment has …
life expectancy of people living with HIV (PLWH). However, the expansion of treatment has …
HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT …
A Hachiya, B Marchand, KA Kirby, E Michailidis… - Journal of Biological …, 2012 - ASBMB
Polymorphisms have poorly understood effects on drug susceptibility and may affect the
outcome of HIV treatment. We have discovered that an HIV-1 reverse transcriptase (RT) …
outcome of HIV treatment. We have discovered that an HIV-1 reverse transcriptase (RT) …