Neuromuscular disorders encompass a heterogeneous group of conditions that impair the
function of muscles, motor neurons, peripheral nerves, and neuromuscular junctions. Being …

The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins
acting as ligand-activated transcription factors. Functionally, NRs are essential in …

Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …

Acute respiratory distress syndrome is associated with a robust inflammatory response that
damages the vascular endothelium, impairing gas exchange. While restoration of …

Duchenne muscular dystrophy (DMD) affects myofibers and muscle stem cells, causing
progressive muscle degeneration and repair defects. It was unknown whether dystrophic …

Recent studies demonstrate that metabolic disturbance, such as augmented glycolysis,
contributes to fibrosis. The molecular regulation of this metabolic perturbation in fibrosis …

Muscle progenitor cell fusion is required for the formation and regeneration of
multinucleated skeletal muscle fibers. Chronic muscle regeneration in Duchenne muscular …

ABSTRACT DNA methylation can affect tissue-specific gene transcription in ways that are
difficult to discern from studies focused on genome-wide analyses of differentially …

Background Recent advancements in understanding β-escin action provide basis for new
therapeutic claims for the drug. β-escin-evoked attenuation of NF-κB-dependent signaling …

Successful muscle regeneration following injury is essential for functional homeostasis of
skeletal muscles. Krüppel-like factor 15 (KLF15) is a metabolic transcriptional regulator in …