The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Background: Cancer has been considered to be a global health concern due to the impact of
disease on the quality of life. The continual increase of cancer cases as well as the …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

A novel series of benzo [a] phenazin derivatives bearing alkylamino side chains were
designed, synthesized and evaluated for their topoisomerases inhibitory activity as well as …

Nickel (II) complexes containing p-substitute (–H,–CI,–CH3,–OCH3)
isonitrosoacetophenone-based bis (oxime) ligands were synthesized by metal template …

A series of pyrazoline derivatives (5) were synthesized in 92–96% yields from chalcones (3)
and hydrazides (4). Subsequently, topo-I and IIα-mediated relaxation and antiproliferative …

In order to develop potent anticaner agents, a novel series of 3-(1H-indol-3-yl)-2, 3, 3a, 4-
tetrahydrothiochromeno [4, 3-c] pyrazole derivatives were synthesized. Structures of all …

Colorectal cancer (CRC) is the third most common cancer globally, with high mortality.
Metastatic CRC is incurable in most cases, and multiple drug therapy can increase patients' …

Two new spiro-acridines were synthesized by introducing cyano-N-acylhydrazone between
the acridine and phenyl rings followed by spontaneous cyclization. The final compounds (E) …

The synthesis of new 3-cyano-2-substituted pyridines bearing various pharmacophores and
functionalities at position 2 is described. The synthesized compounds were evaluated for …