Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …

Objective: Humans and mice with loss-of-function variants of genes in the TGF-β
(transforming growth factor beta) signaling pathway develop aortic aneurysms. These …

Studying the generation of biomechanical force and how this force drives cell and tissue
morphogenesis is challenging for understanding the mechanical mechanisms underlying …

Cardiac muscle myosin regulatory light chain (RLC) is constitutively phosphorylated at∼ 0.4
mol phosphate/mol RLC in normal hearts, and phosphorylation is maintained by balanced …

Abstract Protein phosphatase 1 (PP1) is a key regulator of cardiac function through
dephosphorylating serine/threonine residues within target proteins to oppose the function of …

The physiological importance of cardiac myosin regulatory light chain (RLC)
phosphorylation by its dedicated cardiac myosin light chain kinase has been established in …

Alternative splicing of exon24 (E24) of myosin phosphatase targeting subunit 1 (Mypt1) by
setting sensitivity to nitric oxide (NO)/cGMP-mediated relaxation is a key determinant of …

Purinergic P2Y receptors are a family of eight G protein-coupled receptors (P2Y1, 2, 4, 6, 11,
12, 13, 14) that are activated by nucleotides to elicit both vasoconstriction and vasodilation …

The molecular mechanisms of regulation of myometrial contractility, and, hence, the
mechanisms of regulation of the onset of labor and delivery during pregnancy have been an …

Background: Hypertrophic Cardiomyopathy (HCM) is one of the most prevalent heart
diseases characterized by ventricular and septal hypertrophy, myocardial fibrosis and …