Viral systems such as wild‐type viruses, viral vectors, and virus‐like particles are essential
components of modern biotechnology and medicine. Despite their importance, the …

Viruses are diverse pathogens that use host factors to enter cells and cause disease.
Imaging the entry and replication phases of viruses and their interactions with host factors is …

The SARS-CoV-2 pandemic has made it clear that we have a desperate need for antivirals.
We present work that the mammalian SKI complex is a broad-spectrum, host-directed …

Eosinophils, previously considered terminally differentiated effector cells, have multifaceted
functions in tissues. We previously found that allergic mice with eosinophil-rich inflammation …

Madin-Darby canine kidney (MDCK) cells are widely used in basic research and for the
propagation of influenza A viruses (IAV) for vaccine production. To identify targets for …

Influenza viruses infect millions of humans every year causing an estimated 400,000 deaths
globally. Due to continuous virus evolution current vaccines provide only limited protection …

Cell cultured-based influenza virus production is a viable option for vaccine manufacturing.
In order to achieve a high concentration of viable cells, is requirement to have not only …

A large group of biopharmaceuticals is produced in cell lines. The yield of such products can
be increased by genetic engineering of the corresponding cell lines. The prediction of …

Viral transduction is a main route for gene transfer to producer cells in biomanufacturing.
Designing a transduction-based biomanufacturing process poses significant challenges …

Uncovering how the host immune system effectively responds to influenza virus infections is
critical to understanding influenza pathogenesis. There are currently four known types of …