Mechanistic modeling of viral particle production
Viral systems such as wild‐type viruses, viral vectors, and virus‐like particles are essential
components of modern biotechnology and medicine. Despite their importance, the …
components of modern biotechnology and medicine. Despite their importance, the …
Imaging flow cytometry and confocal immunofluorescence microscopy of virus-host cell interactions
RD McClelland, TN Culp, DJ Marchant - Frontiers in Cellular and …, 2021 - frontiersin.org
Viruses are diverse pathogens that use host factors to enter cells and cause disease.
Imaging the entry and replication phases of viruses and their interactions with host factors is …
Imaging the entry and replication phases of viruses and their interactions with host factors is …
The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses
S Weston, L Baracco, C Keller… - Proceedings of the …, 2020 - National Acad Sciences
The SARS-CoV-2 pandemic has made it clear that we have a desperate need for antivirals.
We present work that the mammalian SKI complex is a broad-spectrum, host-directed …
We present work that the mammalian SKI complex is a broad-spectrum, host-directed …
Eosinophil responses at the airway epithelial barrier during the early phase of influenza A virus infection in C57BL/6 mice
M Tiwary, RJ Rooney, S Liedmann, KS LeMessurier… - Cells, 2021 - mdpi.com
Eosinophils, previously considered terminally differentiated effector cells, have multifaceted
functions in tissues. We previously found that allergic mice with eosinophil-rich inflammation …
functions in tissues. We previously found that allergic mice with eosinophil-rich inflammation …
Absolute quantification of viral proteins during single-round replication of MDCK suspension cells
Madin-Darby canine kidney (MDCK) cells are widely used in basic research and for the
propagation of influenza A viruses (IAV) for vaccine production. To identify targets for …
propagation of influenza A viruses (IAV) for vaccine production. To identify targets for …
Impact of oseltamivir treatment on influenza A and B virus dynamics in human volunteers
KL Hooker, VV Ganusov - Frontiers in Microbiology, 2021 - frontiersin.org
Influenza viruses infect millions of humans every year causing an estimated 400,000 deaths
globally. Due to continuous virus evolution current vaccines provide only limited protection …
globally. Due to continuous virus evolution current vaccines provide only limited protection …
Impact of influenza A virus infection on growth and metabolism of suspension MDCK cells using a dynamic model
Cell cultured-based influenza virus production is a viable option for vaccine manufacturing.
In order to achieve a high concentration of viable cells, is requirement to have not only …
In order to achieve a high concentration of viable cells, is requirement to have not only …
Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine …
A large group of biopharmaceuticals is produced in cell lines. The yield of such products can
be increased by genetic engineering of the corresponding cell lines. The prediction of …
be increased by genetic engineering of the corresponding cell lines. The prediction of …
Efficient Simulation of Viral Transduction and Propagation for Biomanufacturing
Viral transduction is a main route for gene transfer to producer cells in biomanufacturing.
Designing a transduction-based biomanufacturing process poses significant challenges …
Designing a transduction-based biomanufacturing process poses significant challenges …
[图书][B] Investigating Effects of the Influenza NS1 Protein on Host Immune Responses against Influenza A and D Viruses
RMK Skelton - 2021 - search.proquest.com
Uncovering how the host immune system effectively responds to influenza virus infections is
critical to understanding influenza pathogenesis. There are currently four known types of …
critical to understanding influenza pathogenesis. There are currently four known types of …