Metastasis: new functional implications of platelets and megakaryocytes
R Leblanc, O Peyruchaud - Blood, The Journal of the American …, 2016 - ashpublications.org
Platelets are essential components of hemostasis. Due to a plethora of factors released on
activation, platelet functions are also connected to tumor growth, notably by acting on …
activation, platelet functions are also connected to tumor growth, notably by acting on …
Hematopoietic stem cell niche in health and disease
Regulation of stem cells in adult tissues is a key determinant of how well an organism can
respond to the stresses of physiological challenge and disease. This is particularly true of …
respond to the stresses of physiological challenge and disease. This is particularly true of …
Lung megakaryocytes display distinct transcriptional and phenotypic properties
Megakaryocytes (MKs) are responsible for platelet biogenesis, which is believed to occur
canonically in adult bone marrow (BM) and in the fetal liver during development. However …
canonically in adult bone marrow (BM) and in the fetal liver during development. However …
[HTML][HTML] Craniofacial bone tissue engineering: current approaches and potential therapy
A Aghali - Cells, 2021 - mdpi.com
Craniofacial bone defects can result from various disorders, including congenital
malformations, tumor resection, infection, severe trauma, and accidents. Successfully …
malformations, tumor resection, infection, severe trauma, and accidents. Successfully …
[HTML][HTML] High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production
Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also
regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic …
regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic …
Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning
Successful hematopoietic stem cell (HSC) transplantation requires donor HSC engraftment
within specialized bone marrow microenvironments known as HSC niches. We have …
within specialized bone marrow microenvironments known as HSC niches. We have …
Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and laminin
Megakaryocytes associate with the bone marrow vasculature where they convert their
cytoplasm into proplatelets that protrude through the vascular endothelium into the lumen …
cytoplasm into proplatelets that protrude through the vascular endothelium into the lumen …
[HTML][HTML] Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation
SY Heazlewood, RJ Neaves, B Williams, DN Haylock… - Stem cell …, 2013 - Elsevier
We report transplanted hemopoietic stem cells (HSC) preferentially lodge within two cells of
mature megakaryocytes (MM). With both populations comprising~ 0.2% of bone marrow …
mature megakaryocytes (MM). With both populations comprising~ 0.2% of bone marrow …
Bone marrow niche in immune thrombocytopenia: a focus on megakaryopoiesis
E Khodadi, AA Asnafi, S Shahrabi, M Shahjahani… - Annals of …, 2016 - Springer
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased
bleeding tendency and thrombocytopenia. In fact, the precise pathogenesis of this disease is …
bleeding tendency and thrombocytopenia. In fact, the precise pathogenesis of this disease is …
The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control
Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday
production and release of millions of platelets into the bloodstream. Since the discovery and …
production and release of millions of platelets into the bloodstream. Since the discovery and …