Clocking in to immunity
Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …
diversity of physiological systems. It has long been established that the circadian clockwork …
Medicine in the fourth dimension
The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …
even more when translating to the bedside. Circadian biology is becoming a critical factor for …
Corticosteroids: mechanisms of action in health and disease
S Ramamoorthy, JA Cidlowski - Rheumatic Disease …, 2016 - rheumatic.theclinics.com
Corticosteroids are a class of steroid hormones released by the adrenal cortex, which
includes glucocorticoids and mineralocorticoids. 1 However, the term “corticosteroids” is …
includes glucocorticoids and mineralocorticoids. 1 However, the term “corticosteroids” is …
Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases
Therapeutic glucocorticoids have been widely used in rheumatic diseases since they
became available over 60 years ago. Despite the advent of more specific biologic therapies …
became available over 60 years ago. Despite the advent of more specific biologic therapies …
Training the circadian clock, clocking the drugs, and drugging the clock to prevent, manage, and treat chronic diseases
Daily rhythms in behavior, physiology, and metabolism are an integral part of homeostasis.
These rhythms emerge from interactions between endogenous circadian clocks and …
These rhythms emerge from interactions between endogenous circadian clocks and …
Systems chronotherapeutics
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
Foundations of circadian medicine
The circadian clock is an evolutionarily highly conserved endogenous timing program that
structures physiology and behavior according to the time of day. Disruption of circadian …
structures physiology and behavior according to the time of day. Disruption of circadian …
Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?
It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
Dosing time matters
Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …