Hepatitis B virus has been evolving gradually over a long period of time, resulting in a large
amount of genetic diversity, despite the constraints imposed by the complex genetic …

Publisher Summary Although most living biological systems have developed intricate
mechanisms to keep the genetic information stable, many viruses, including hepatitis B virus …

We conducted a large-scale survey to determine the frequency and clinical significance of
mutations in the pre-core region of hepatitis B virus (HBV). Sera from 263 patients with …

Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a
major health problem, with more than 350 million chronically infected people worldwide and …

States that nucleotide substitutions in viral genomes can have several effects, including
evasion of vaccine-induced or natural immunity, drug resistance and more. RNA viruses and …

Sera from 410 patients from the Wuhan area in the central part of China with the diagnosis of
chronic liver disease were analyzed for markers of hepatitis B, C and D virus infections. All …

Background/Aims: Despite anti-HBs immunoglobulin therapy, hepatitis B virus (HBV)
infection recurs in a high proportion of patients transplanted for HBsAg positive and serum …

This study aimed to investigate the ratios of precore stop mutant (codon 28; TGG to TAG) to
total viremia in 53 HBeAg-positive patients with chronic hepatitis B by amplification-created …

Worldside viral hepatitis is still recognized as a mojor problem particularly in developing
countries. During the past two decades there has been important progress in the field of viral …

Hepatitis Be antigen (HBeAg)‐negative chronic hepatitis B (CHB) is associated with
hepatitis B virus (HBV) variants harbouring changes in the precore region. Most commonly …