Creative biological lignin conversion routes toward lignin valorization

ZH Liu, BZ Li, JS Yuan, YJ Yuan - Trends in Biotechnology, 2022 - cell.com
Lignin, the largest renewable aromatic resource, is a promising alternative feedstock for the
sustainable production of various chemicals, fuels, and materials. Despite this potential …

Innovation trends in industrial biotechnology

J Nielsen, CB Tillegreen, D Petranovic - Trends in biotechnology, 2022 - cell.com
Microbial fermentations are used for the sustainable production of a range of products. Due
to increasing trends in the food sector toward plant-based foods and meat and dairy product …

De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …

Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast

SA Bradley, BJ Lehka, FG Hansson… - Nature Chemical …, 2023 - nature.com
Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with
marketed pharmaceutical activities against a wide range of indications, including cancer …

Discovery of isoflavone phytoalexins in wheat reveals an alternative route to isoflavonoid biosynthesis

G Polturak, RC Misra, A El-Demerdash, C Owen… - Nature …, 2023 - nature.com
Isoflavones are a group of phenolic compounds mostly restricted to plants of the legume
family, where they mediate important interactions with plant-associated microbes, including …

A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin

H Zhang, Z Li, S Zhou, SM Li, H Ran, Z Song… - Nature …, 2022 - nature.com
Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a
type III polyketide synthase (PKS) using one p-coumaroyl-CoA and three malonyl-CoA …

Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants

HT Wang, ZL Wang, K Chen, MJ Yao, M Zhang… - Nature …, 2023 - nature.com
Apiose is a natural pentose containing an unusual branched-chain structure. Apiosides are
bioactive natural products widely present in the plant kingdom. However, little is known on …

De novo biosynthesis of anticarcinogenic icariin in engineered yeast

T An, G Lin, Y Liu, L Qin, Y Xu, X Feng, C Li - Metabolic Engineering, 2023 - Elsevier
Icariin (ICA) has wide applications in nutraceuticals and medicine with strong anticancer
activities. However, the structural complexity and low abundance in plants of ICA lead to the …

Synthesis of bioengineered heparin by recombinant yeast Pichia pastoris

Y Zhang, Y Wang, Z Zhou, P Wang, X Xi, S Hu… - Green …, 2022 - pubs.rsc.org
Heparin, the most widely used anticoagulant drug, is mainly acquired from livestock.
Variable structures and contaminations of other glycosaminoglycans of animal-sourced …

[HTML][HTML] 黄酮类化合物合成生物学研究进展

林春草, 陈大伟, 戴均贵 - 药学学报, 2022 - html.rhhz.net
黄酮类化合物是植物中广泛分布的一大类次级代谢产物, 已报道的化合物超过10 000 种,
结构多样且部分具有抗癌, 抗炎等重要的药理活性. 黄酮类化合物生物合成相关的基因及酶 …