Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Cognitive dysfunction is an important non-motor symptom in amyotrophic lateral sclerosis
(ALS) that has a negative impact on survival and caregiver burden. It shows a wide spectrum …

Synapse loss has been considered as a major pathological change in Alzheimer's disease
(AD). It remains unclear about whether and how synapse loss relates to functional and …

Background Internet gaming disorder (IGD) is an ideal model to study the mechanisms
underlying synaptic deficits in addiction as it eliminates the confounding effects of substance …

Background The nucleus basalis of Meynert (NBM) is known to play a crucial role in the
development and pathogenesis of Alzheimer's Disease (AD), particularly the cholinergic …

Depression with an average prevalence of 25–40% is a serious condition in amyotrophic
lateral sclerosis (ALS) that can impact quality of life and survival of patients and caregiver …

Synapses are implicated in many neuropsychiatric illnesses. Here, we provide an overview
of in vivo techniques to index synaptic markers in patients. Several positron emission …

Background Psychotic disorders have long been considered neurodevelopmental disorders
where excessive synaptic pruning and cortical volume loss are central to disease pathology …

Amyotrophic lateral sclerosis (ALS) is a disease leading to progressive motor degeneration
and ultimately death. It is a complex disease that can take a significantly long time to be …

Synapses are integral for healthy brain function and are becoming increasingly recognized
as key structures in the early stages of brain disease. Understanding the pathological …