Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

Nowadays we understand cell membranes not as a simple double lipid layer but as a
collection of complex and dynamic protein–lipid structures and microdomains that serve as …

STUDY QUESTION Do mitochondria-targeted therapies reverse ageing-and oxidative stress-
induced spindle defects in oocytes from mice and humans? SUMMARY ANSWER Exposure …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Acrolein is a highly reactive unsaturated aldehyde that is formed during the burning of
gasoline and diesel fuels, cigarettes, woods and plastics. In addition, acrolein is generated …

Increased tau acetylation at K274 and K281 has been observed in the brains of Alzheimer's
disease (AD) patients and animal models, and mitochondrial dysfunction are noticeable and …

The classic heat shock (stress) response (HSR) was originally attributed to protein
denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances …

The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from
the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and …

Arimoclomol is a hydroxylamine derivative, a group of compounds which have unique
properties as co-inducers of heat shock protein expression, but only under conditions of …

Cardiac fibrosis (CF) is considered an ultimate common pathway of a wide variety of heart
diseases in response to diverse pathological and pathophysiological stimuli. Mitochondria …