Chemistries for DNA nanotechnology

M Madsen, KV Gothelf - Chemical reviews, 2019 - ACS Publications
The predictable nature of DNA interactions enables the programmable assembly of highly
advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger …

Cancer biomarker detection: recent achievements and challenges

L Wu, X Qu - Chemical Society Reviews, 2015 - pubs.rsc.org
The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT

R Jungmann, MS Avendaño, JB Woehrstein, M Dai… - Nature …, 2014 - nature.com
Super-resolution fluorescence microscopy is a powerful tool for biological research, but
obtaining multiplexed images for a large number of distinct target species remains …

Playing with the molecules of life

DD Young, PG Schultz - ACS chemical biology, 2018 - ACS Publications
Our understanding of the complex molecular processes of living organisms at the molecular
level is growing exponentially. This knowledge, together with a powerful arsenal of tools for …

Targeting the N terminus for site-selective protein modification

CB Rosen, MB Francis - Nature chemical biology, 2017 - nature.com
The formation of well-defined protein bioconjugates is critical for many studies and
technologies in chemical biology. Tried-and-true methods for accomplishing this typically …

Scaling by shrinking: empowering single-cell'omics' with microfluidic devices

SM Prakadan, AK Shalek, DA Weitz - Nature Reviews Genetics, 2017 - nature.com
Recent advances in cellular profiling have demonstrated substantial heterogeneity in the
behaviour of cells once deemed'identical', challenging fundamental notions of …

Beyond traditional biosensors: recent advances in gold nanoparticles modified electrodes for biosensing applications

G Siciliano, A Alsadig, MS Chiriacò, A Turco… - Talanta, 2024 - Elsevier
Gold nanoparticles (AuNPs) have emerged as powerful tools in the construction of highly
sensitive electrochemical biosensors. Their unique properties, such as the ability to serve as …

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

JY Axup, KM Bajjuri, M Ritland… - Proceedings of the …, 2012 - National Acad Sciences
Antibody-drug conjugates (ADCs) allow selective targeting of cytotoxic drugs to cancer cells
presenting tumor-associated surface markers, thereby minimizing systemic toxicity …

Applying CRISPR-Cas12a as a signal amplifier to construct biosensors for non-DNA targets in ultralow concentrations

J Li, S Yang, C Zuo, L Dai, Y Guo, G Xie - Acs Sensors, 2020 - ACS Publications
Efficient signal amplification is essential to construct ultrasensitive biosensors for biologically
relevant species with abundant concomitant interferences. Here, we apply LbaCas12a as a …

Oriented immobilization of proteins on solid supports for use in biosensors and biochips: a review

Y Liu, J Yu - Microchimica Acta, 2016 - Springer
Immobilization of proteins on a solid support is critical with respect to the fabrication and
performance of biosensors and biochips. Protein attachment with a preferable orientation …