Although systemic immunotherapy has achieved durable responses and improved survival
for certain patients and cancer types, low response rates and immune system-related …

Accumulating research suggests that the tumor immune microenvironment (TIME) plays an
essential role in regulation of tumor growth and metastasis. The cellular and molecular …

Cancer metastases and recurrence after surgical resection remain an important cause of
treatment failure. Here we demonstrate a general strategy to fabricate personalized …

Existing strategies to enhance peptide immunogenicity for cancer vaccination generally
require direct peptide alteration, which, beyond practical issues, may impact peptide …

Bladder cancer is an important public health concern owing to its prevalence, high
recurrence risk and treatment failures. Maintaining the equilibrium between prompt and …

The development of therapeutic cancer vaccines as a means to generate immune reactivity
against tumors has been explored since the early discovery of tumor-specific antigens by …

Head and neck cancers are a heterogeneous group of tumors that are highly aggressive
and collectively represent the sixth most common cancer worldwide. Ninety percent of head …

Owing to the fast-paced growth and cross-infiltration of oncology, immunology and
molecular biology, tumor immunotherapy technology represented by immune checkpoint …

RNA molecules (eg, siRNA, microRNA, and mRNA) have shown tremendous potential for
immunomodulation and cancer immunotherapy. They can activate both innate and adaptive …

Given that vascular endothelial growth factor (VEGF) and placental growth factor (PIGF),
over-expressed in breast cancer cells and M2-like tumor-associated macrophages (M2 …