I summarize recent computational and experimental work that addresses the inherent
variability in the synaptic and intrinsic conductances in normal healthy brains and shows that …

There are now a reasonable number of invertebrate central pattern generator (CPG) circuits
described in sufficient detail that a mechanistic explanation of how they work is possible …

Scientific models are abstractions that aim to explain natural phenomena. A successful
model shows how a complex phenomenon arises from relatively simple principles while …

Breathing in mammals is a seemingly straightforward behaviour controlled by the brain. A
brainstem nucleus called the preBötzinger Complex sits at the core of the neural circuit …

Neuroscientists have often described the adult brain in similar terms to an electronic circuit
board–dependent on fixed, precise connectivity. However, with the advent of technologies …

Recent work argues that similar network performance can result from highly variable sets of
network parameters, raising the question of whether neuromodulation can be reliable across …

Neurons in cold-blooded animals remarkably maintain their function over a wide range of
temperatures, even though the rates of many cellular processes increase twofold, threefold …

Traditional approaches to the problem of parameter estimation in biophysical models of
neurons and neural networks usually adopt a global search algorithm (for example, an …

Neurons that respond selectively but in an invariant manner to a given feature of natural
stimuli have been observed across species and systems. Such responses emerge in higher …

Constructing physiologically relevant compartmental models of neurones is critical for
understanding neuronal activity and function. We recently suggested that measurements …