[HTML][HTML] TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance
A Yang, X Bofill-De Ros, R Stanton, TJ Shao… - Nature …, 2022 - nature.com
TENTs generate miRNA isoforms by 3'tailing. However, little is known about how tailing
regulates miRNA function. Here, we generate isogenic HEK293T cell lines in which TENT2 …
regulates miRNA function. Here, we generate isogenic HEK293T cell lines in which TENT2 …
[HTML][HTML] Delivery of active AKT1 to human cells
T Siddika, N Balasuriya, MI Frederick, P Rozik… - Cells, 2022 - mdpi.com
Protein kinase B (AKT1) is a serine/threonine kinase and central transducer of cell survival
pathways. Typical approaches to study AKT1 biology in cells rely on growth factor or insulin …
pathways. Typical approaches to study AKT1 biology in cells rely on growth factor or insulin …
[HTML][HTML] miRNA-dependent regulation of AKT1 phosphorylation
MI Frederick, T Siddika, P Zhang, N Balasuriya… - Cells, 2022 - mdpi.com
The phosphoinositide-3-kinase (PI3K)/AKT pathway regulates cell survival and is over-
activated in most human cancers, including ovarian cancer. Following growth factor …
activated in most human cancers, including ovarian cancer. Following growth factor …
[HTML][HTML] Terminal uridylyltransferases TUT4/7 regulate microRNA and mRNA homeostasis
P Zhang, MI Frederick, IU Heinemann - Cells, 2022 - mdpi.com
The terminal nucleotidyltransferases TUT4 and TUT7 (TUT4/7) regulate miRNA and mRNA
stability by 3′ end uridylation. In humans, TUT4/7 polyuridylates both mRNA and pre …
stability by 3′ end uridylation. In humans, TUT4/7 polyuridylates both mRNA and pre …