Skeletal infections: microbial pathogenesis, immunity and clinical management

EA Masters, BF Ricciardi, KLM Bentley… - Nature Reviews …, 2022 - nature.com
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …

Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections

MA Azad, R Patel - Clinical Microbiology Reviews, 2024 - Am Soc Microbiol
Implant-associated infections (IAIs) pose serious threats to patients and can be associated
with significant morbidity and mortality. These infections may be difficult to diagnose due, in …

Comparison of the BioFire joint infection panel to 16S ribosomal RNA gene-based targeted metagenomic sequencing for testing synovial fluid from patients with knee …

MA Azad, MJ Wolf, AP Strasburg… - Journal of clinical …, 2022 - Am Soc Microbiol
The diagnosis of periprosthetic joint infection (PJI) is challenging, often requiring multiple
clinical specimens and diagnostic techniques, some with prolonged result turnaround times …

Short-term outcomes of phage-antibiotic combination treatment in adult patients with periprosthetic hip joint infection

E Fedorov, A Samokhin, Y Kozlova, S Kretien… - Viruses, 2023 - mdpi.com
Implant-associated infections are the most costly problem in modern orthopedics due to the
continued increase in the occurrence of antibiotic-resistant bacterial strains that requires the …

[HTML][HTML] Nanocomposite orthopaedic bone cement combining long-acting dual antimicrobial drugs

L Yang, AA Yergeshov, Y Al-Thaher… - Biomaterials …, 2023 - Elsevier
Antibiotic loaded bone cements are widely used in total joint replacement (TJR); despite
many limitations such as a burst release which leads to antibiotic concentration below …

Titanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cells

W de Souza, S Gemini-Piperni, L Grenho… - Biomaterials …, 2023 - pubs.rsc.org
Titanium (Ti) and its alloys are the most widely used metallic biomaterials in total joint
replacement; however, increasing evidence supports the degradation of its surface due to …

Development of a preoperative risk calculator for reinfection following revision surgery for periprosthetic joint infection

C Klemt, V Tirumala, EJ Smith, A Padmanabha… - The Journal of …, 2021 - Elsevier
Background A recent systematic review demonstrated that reinfection rates following
eradication of hip and knee periprosthetic joint infection (PJI) may be as high as 29%. This …

Promising applications of D-amino acids in periprosthetic joint infection

M Caldwell, M Hughes, F Wei, C Ngo, R Pascua… - Bone Research, 2023 - nature.com
Due to the rise in our aging population, a disproportionate demand for total joint arthroplasty
(TJA) in the elderly is forecast. Periprosthetic joint infection (PJI) represents one of the most …

Eucalyptus globulus essential oil thin film polymerized by cold plasma on Ti6Al4V: Sterilization effect, antibacterial activity, adhesion, and viability of mesenchymal …

M da Silva Bullmann, VV de Castro… - Plasma Processes …, 2023 - Wiley Online Library
This work aims to evaluate the characterization, antibacterial activity, and mesenchymal
stem cell (MSC) viability in films obtained by cold plasma polymerization, from the essential …

Bacterial pathogens and in-hospital mortality in revision surgery for periprosthetic joint infection of the hip and knee: analysis of 346 patients

F Migliorini, CD Weber, A Bell, M Betsch… - European Journal of …, 2023 - Springer
Introduction The management of periprosthetic joint infections (PJI) of the lower limb is
challenging, and evidence-based recommendations are lacking. The present clinical …