Safety aspects of the use of quercetin as a dietary supplement

S Andres, S Pevny, R Ziegenhagen… - Molecular nutrition & …, 2018 - Wiley Online Library
The flavonoid quercetin is frequently found in low amounts as a secondary plant metabolite
in fruits and vegetables. Isolated quercetin is also marketed as a dietary supplement, mostly …

Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

S Patra, B Pradhan, R Nayak, C Behera, S Das… - Phytomedicine, 2021 - Elsevier
Background Epidemiological studies has revealed that a diet rich in fruits and vegetables
could lower the risk of certain cancers. In this setting, natural polyphenols are potent …

Oral delivery of anticancer drugs: challenges and opportunities

K Thanki, RP Gangwal, AT Sangamwar… - Journal of controlled …, 2013 - Elsevier
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

Quercetin.

GS Kelly - Alternative medicine review, 2011 - search.ebscohost.com
The article features quercetin, one of the subclasses of flavonoid compounds. The dietary
presence of quercetin is provided in foods and in the form of quercetin glycosides. Factors …

A comprehensive review on pharmacotherapeutics of herbal bioenhancers

GB Dudhatra, SK Mody, MM Awale… - The Scientific World …, 2012 - Wiley Online Library
In India, Ayurveda has made a major contribution to the drug discovery process with new
means of identifying active compounds. Recent advancement in bioavailability …

Quercetin: a potential drug to reverse multidrug resistance

C Chen, J Zhou, C Ji - Life sciences, 2010 - Elsevier
This review centers on recent findings with respect to modulating cancer multidrug
resistance (MDR) with the well-known flavonoid quercetin. After a short introduction of …

Herb–drug interactions: challenges and opportunities for improved predictions

SJ Brantley, AA Argikar, YS Lin, S Nagar… - Drug Metabolism and …, 2014 - ASPET
Supported by a usage history that predates written records and the perception that “natural”
ensures safety, herbal products have increasingly been incorporated into Western health …

Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin

JS Choi, YJ Piao, KW Kang - Archives of pharmacal research, 2011 - Springer
Quercetin, a flavonoid, is an inhibitor of P-glycoprotein-mediated efflux transport, and its
oxidative metabolism is catalyzed by CYP enzymes. Thus, it is expected that the …

Molecular mechanisms of action of quercetin in cancer: recent advances

D Kashyap, S Mittal, K Sak, P Singhal, HS Tuli - Tumor Biology, 2016 - Springer
In the last few decades, the scientific community has discovered an immense potential of
natural compounds in the treatment of dreadful diseases such as cancer. Besides the …

[HTML][HTML] Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism

B Peterson, M Weyers, JH Steenekamp, JD Steyn… - Pharmaceutics, 2019 - mdpi.com
Many new chemical entities are discovered with high therapeutic potential, however, many
of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility …