Challenges and future directions for studying effects of host genetics on the gut microbiome
The human gut microbiome is a complex ecosystem that is involved in its host's metabolism,
immunity and health. Although interindividual variations in gut microbial composition are …
immunity and health. Although interindividual variations in gut microbial composition are …
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Disentangling the genetic basis of rhizosphere microbiome assembly in tomato
Microbiomes play a pivotal role in plant growth and health, but the genetic factors involved in
microbiome assembly remain largely elusive. Here, we map the molecular features of the …
microbiome assembly remain largely elusive. Here, we map the molecular features of the …
Role of the microbiome in gut-heart-kidney cross talk
G Glorieux, SK Nigam, R Vanholder… - Circulation …, 2023 - Am Heart Assoc
Homeostasis is a prerequisite for health. When homeostasis becomes disrupted, dysfunction
occurs. This is especially the case for the gut microbiota, which under normal conditions …
occurs. This is especially the case for the gut microbiota, which under normal conditions …
Compositional data analysis of microbiome and any-omics datasets: a validation of the additive logratio transformation
Microbiome and omics datasets are, by their intrinsic biological nature, of high
dimensionality, characterized by counts of large numbers of components (microbial genes …
dimensionality, characterized by counts of large numbers of components (microbial genes …
Gut microbiome studies in CKD: opportunities, pitfalls and therapeutic potential
H Krukowski, S Valkenburg, AM Madella… - Nature Reviews …, 2023 - nature.com
Interest in gut microbiome dysbiosis and its potential association with the development and
progression of chronic kidney disease (CKD) has increased substantially in the past 6 years …
progression of chronic kidney disease (CKD) has increased substantially in the past 6 years …
Waste not, want not: revisiting the analysis that called into question the practice of rarefaction
PD Schloss - Msphere, 2024 - Am Soc Microbiol
ABSTRACT In 2014, McMurdie and Holmes published the provocatively titled “Waste not,
want not: why rarefying microbiome data is inadmissible.” The claims of their study have …
want not: why rarefying microbiome data is inadmissible.” The claims of their study have …
[HTML][HTML] Diurnal oscillations in gut bacterial load and composition eclipse seasonal and lifetime dynamics in wild meerkats
A Risely, K Wilhelm, T Clutton-Brock… - Nature …, 2021 - nature.com
Circadian rhythms in gut microbiota composition are crucial for metabolic function, yet the
extent to which they govern microbial dynamics compared to seasonal and lifetime …
extent to which they govern microbial dynamics compared to seasonal and lifetime …
Overview of data preprocessing for machine learning applications in human microbiome research
Although metagenomic sequencing is now the preferred technique to study microbiome-host
interactions, analyzing and interpreting microbiome sequencing data presents challenges …
interactions, analyzing and interpreting microbiome sequencing data presents challenges …
Gut microbiome signatures and host colonization with multidrug-resistant bacteria
The human gut is host to a diverse range of microorganisms that offer protection against
colonization by multidrug-resistant bacteria. Antibiotic use, medications, health conditions …
colonization by multidrug-resistant bacteria. Antibiotic use, medications, health conditions …