P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …

The importance of drug transporters as one of the determinants of pharmacokinetics has
become increasingly evident [1]. While much research has been conducted focusing the role …

The properties of intestinal folate absorption were documented decades ago. However, it
was only recently that the proton-coupled folate transporter (PCFT) was identified and its …

The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X
receptor (PXR) and constitutive androstane receptor (CAR), is involved in the regulation of …

Vitamin D receptor (VDR) mediates vitamin D signaling involved in bone metabolism,
cellular growth and differentiation, cardiovascular function, and bile acid regulation. Mice …

Altered drug concentrations may induce unexpected toxicity or treatment failure; thus,
understanding the factors that alter the pharmacokinetic profiles of drugs is crucial for …

Purpose This study aimed to investigate the effects of 1α, 25-dihydroxyvitamin D3 (1, 25
(OH) 2D3) on the expression levels of organic cation/carnitine transporter 1 (OCTN1) as well …

Organic anion-transporting polypeptide 1A2 (OATP1A2)(gene symbol, SLCO1A2) mediates
cellular uptake of a wide range of endogenous substrates, as well as drugs and xenobiotics …

The compound 1α, 25-Dihydroxyvitamin D3 (1, 25 (OH) 2D3) is the active form of vitamin D3
and a representative ligand of the vitamin D receptor (VDR). Previous studies have …

In this study, possible changes in the expression of rat organic cationic transporters (rOCTs)
and rat multidrug and toxin extrusion proteins (rMATEs) following treatment with 1α, 25 …