Hypertension is the most frequent medical complication occurring during pregnancy. In this
chapter, we aim to address the genetic contribution to these disorders, with specific focus on …

Both preeclampsia and the HELLP syndrome have their origin in the placenta. The aim of
this study is to review genetic factors involved in development of preeclampsia and the …

A remarkable characteristic of the human major histocompatibility complex (MHC) is its
extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC …

Preeclampsia (PE) is one of the main causes of maternal and fetal morbidity and mortality in
the world, causing nearly 40% of births delivered before 35 weeks of gestation. PE begins …

Preeclampsia risk is influenced by both the mother's genetic background and the genetics of
her fetus; however, the specific genes responsible for conferring preeclampsia risk have …

Preeclampsia Among African American Pregnant Women: An Updat... : Obstetrical &
Gynecological Survey Preeclampsia Among African American Pregnant Women: An Update …

Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine.
We have performed a genome-wide association study (GWAS) for preeclampsia in …

Black Americans are at increased risk for preeclampsia. Genetic variants in apolipoprotein
L1 (APOL1) account for much of the increased risk for kidney disease in blacks. APOL1 is …

Abstract Endoplasmic reticulum aminopeptidase 1 (ERAP1) and the closely related ERAP2
are involved in the final trimming of peptides within the endoplasmic reticulum for …

Endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 cooperate to trim a vast variety
of antigenic peptide precursors to generate mature epitopes for binding to major …