[HTML][HTML] Computational prediction of formulation strategies for beyond-rule-of-5 compounds
The physicochemical properties of some contemporary drug candidates are moving towards
higher molecular weight, and coincidentally also higher lipophilicity in the quest for …
higher molecular weight, and coincidentally also higher lipophilicity in the quest for …
CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology
Background: Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological
processes and whose dysfunction may contribute to several different diseases, such as …
processes and whose dysfunction may contribute to several different diseases, such as …
MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential
Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …
MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations
P Klosen, S Lapmanee, C Schuster… - Journal of pineal …, 2019 - Wiley Online Library
Melatonin (MLT) exerts its physiological effects principally through two high‐affinity
membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action …
membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action …
Quinone reductase 2 as a promising target of melatonin therapeutic actions
JA Boutin - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: The neurohormone melatonin is secreted by the pineal gland and shows a
circadian rhythm. It has been used in pathological conditions to evaluate its protective …
circadian rhythm. It has been used in pathological conditions to evaluate its protective …
The role and therapeutic potential of melatonin in age‐related ocular diseases
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to
oxidative attacks. In fact, oxidative damage is a major cause of age‐related ocular diseases …
oxidative attacks. In fact, oxidative damage is a major cause of age‐related ocular diseases …
Melatonin receptor ligands: a pharmaco‐chemical perspective
JA Boutin, PA Witt‐Enderby, C Sotriffer… - Journal of pineal …, 2020 - Wiley Online Library
Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …
decades. Inspection of approximately 80 publications in the field revealed that most …
AgPd Nanoparticles Deposited on WO2.72 Nanorods as an Efficient Catalyst for One-Pot Conversion of Nitrophenol/Nitroacetophenone into Benzoxazole …
We report a seed-mediated growth of 2.3 nm AgPd nanoparticles (NPs) in the presence of
40× 5 nm WO2. 72 nanorods (NRs) for the synthesis of AgPd/WO2. 72 composites. The …
40× 5 nm WO2. 72 nanorods (NRs) for the synthesis of AgPd/WO2. 72 composites. The …
Melatonin as an antioxidant for stroke neuroprotection
N Watson, T Diamandis… - Cell …, 2016 - journals.sagepub.com
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone derived from the pineal gland that
has a wide range of clinical applications. While melatonin was originally assessed as a …
has a wide range of clinical applications. While melatonin was originally assessed as a …
The location, physiology, pathology of hippocampus Melatonin MT2 receptor and MT2-selective modulators
Y Feng, X Jiang, W Liu, H Lu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …