Therapeutics for COVID-19

SS Toussi, JL Hammond, BS Gerstenberger… - Nature …, 2023 - nature.com
Vaccines and monoclonal antibody treatments to prevent severe coronavirus disease 2019
(COVID-19) illness were available within a year of the pandemic being declared but there …

Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

D Ao, X He, J Liu, L Xu - Signal Transduction and Targeted Therapy, 2023 - nature.com
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted
in significant casualties and put immense strain on public health systems worldwide, leading …

Risk factors for fungal co-infections in critically ill COVID-19 patients, with a focus on immunosuppressants

OT Ezeokoli, O Gcilitshana, CH Pohl - Journal of Fungi, 2021 - mdpi.com
Severe cases of coronavirus disease 2019 (COVID-19) managed in the intensive care unit
are prone to complications, including secondary infections with opportunistic fungal …

Drugs for COVID-19: An update

J Ceramella, D Iacopetta, MS Sinicropi, I Andreu… - Molecules, 2022 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the seventh
known human coronavirus, and it was identified in Wuhan, Hubei province, China, in 2020. It …

Mechanism of action, resistance, synergism, and clinical implications of azithromycin

M Heidary, A Ebrahimi Samangani… - Journal of clinical …, 2022 - Wiley Online Library
Background Azithromycin (AZM), sold under the name Zithromax, is classified as a
macrolide. It has many benefits due to its immunomodulatory, anti‐inflammatory, and …

Neutrophil autophagy and NETosis in COVID-19: perspectives

R Zhang, C Sun, Y Han, L Huang, H Sheng, J Wang… - Autophagy, 2023 - Taylor & Francis
The COVID-19 pandemic has caused substantial losses worldwide in people's lives, health,
and property. Currently, COVID-19 is still prominent worldwide without any specific drug …

Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization

JA Frontera, S Sabadia, D Yang, A de Havenon… - Journal of the …, 2022 - Elsevier
Background Limited data exists evaluating predictors of long-term outcomes after
hospitalization for COVID-19. Methods We conducted a prospective, longitudinal cohort …

Azithromycin mitigates cisplatin-induced lung oxidative stress, inflammation and necroptosis by upregulating SIRT1, PPARγ, and Nrf2/HO-1 signaling

EHM Hassanein, GA Sayed, AM Alzoghaibi… - Pharmaceuticals, 2022 - mdpi.com
Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin
(CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung …

Efficacy and safety of azithromycin versus placebo to treat lower respiratory tract infections associated with low procalcitonin: a randomised, placebo-controlled …

EL Tsalik, NG Rouphael, RT Sadikot… - The Lancet Infectious …, 2023 - thelancet.com
Background Lower respiratory tract infections are frequently treated with antibiotics, despite
a viral cause in many cases. It remains unknown whether low procalcitonin concentrations …

High levels of the cleaved form of galectin-9 and osteopontin in the plasma are associated with inflammatory markers that reflect the severity of COVID-19 pneumonia

G Bai, D Furushima, T Niki, T Matsuba… - International journal of …, 2021 - mdpi.com
Numbers of patients with coronavirus disease 2019 (COVID-19) have increased rapidly
worldwide. Plasma levels of full-length galectin-9 (FL-Gal9) and osteopontin (FL-OPN) as …